PREGNANCY, HIGH RISK

This study compares two treatments for gestational diabetes—metformin pills versus insulin shots—in 1,572 pregnant women across 20 U.S. sites. The goal is to see if metformin works as well as insulin to prevent serious problems for the baby and mother, and to track the health of …

This study looks at two ways of managing blood sugar during labor in pregnant women with type 1 diabetes. One group will follow a strict target (70-110 mg/dL), while the other will have a more relaxed target (70-140 mg/dL). The goal is to see if the relaxed approach is safe for n…

This study tests whether a seven-day course of three antibiotics (ceftriaxone, clarithromycin, metronidazole) can prolong pregnancy and improve outcomes for pregnant individuals with preterm premature rupture of membranes (PPROM) before 34 weeks. About 56 participants will be ran…

This study tests whether taking the blood thinner Lovenox three times a day works better than the standard twice-a-day schedule for pregnant women at high risk of blood clots. Pregnancy increases clot risk fivefold, and many women on the standard schedule don't get enough protect…

This study looks at whether using a continuous glucose monitor (CGM) instead of traditional fingerstick checks can help pregnant women with type 2 diabetes have healthier babies and better blood sugar control. About 180 women will be randomly assigned to use a CGM or standard car…

This study aims to see if screening for gestational diabetes earlier in pregnancy (first trimester) is feasible and acceptable for high-risk women. About 80 pregnant women at high risk for gestational diabetes will be invited to participate. The goal is to catch the condition soo…

This study tests whether a buprenorphine patch can reduce withdrawal symptoms in pregnant women with opioid use disorder when they start treatment. About 40 participants will receive either the patch or standard care during the required withdrawal period before taking sublingual …

This study tests whether doing a diabetes test right after giving birth (before leaving the hospital) is better than waiting 4-12 weeks, as is standard. It also asks women about their views on heart health programs after pregnancy. About 104 women who had gestational diabetes wil…

This study is following over 267,000 pregnant women in low- and middle-income countries to understand what factors lead to serious problems like stillbirth, maternal death, and preterm birth. Researchers will collect health data from before 20 weeks of pregnancy through the first…