ORAL LEUKOPLAKIA
Clinical trials for ORAL LEUKOPLAKIA explained in plain language.
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Vitamin a derivative patch could reverse oral precancer
Disease control OngoingThis trial tests a sticky patch that releases fenretinide, a vitamin A derivative, directly onto precancerous spots inside the mouth. The goal is to see if the patch can shrink these lesions, reduce their severity under the microscope, and lower genetic changes linked to oral can…
Matched conditions: ORAL LEUKOPLAKIA
Phase: PHASE1 • Sponsor: Ohio State University Comprehensive Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Can a vitamin d gel or light therapy stop precancerous mouth lesions?
Disease control OngoingThis study tests whether a vitamin D-based gel (calcipotriol) or a light-activated treatment (photodynamic therapy) can shrink or eliminate oral leukoplakia, a precancerous condition. Thirty adults with mild to moderate dysplasia will receive one of the two treatments for four we…
Matched conditions: ORAL LEUKOPLAKIA
Phase: PHASE2, PHASE3 • Sponsor: Alexandria University • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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Could a common diabetes drug stop oral cancer before it starts?
Prevention OngoingThis phase 2 trial tests whether metformin, a widely used diabetes drug, can prevent oral cancer in 26 people with precancerous mouth lesions (leukoplakia or erythroplakia). Participants take metformin by mouth, and researchers check if the lesions shrink or disappear. The goal i…
Matched conditions: ORAL LEUKOPLAKIA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Prevention
Last updated Jun 28, 2026 00:00 UTC
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Can a diabetes drug stop oral cancer before it starts?
Prevention OngoingThis study tests whether metformin, a common diabetes drug, can prevent oral cancer in people with precancerous white or red patches in the mouth. About 34 participants will receive either metformin or a placebo for several months. Researchers will check if the patches shrink or …
Matched conditions: ORAL LEUKOPLAKIA
Phase: PHASE2 • Sponsor: University of Arizona • Aim: Prevention
Last updated Jun 27, 2026 12:09 UTC