ORAL CAVITY CANCER

This study tests whether combining two drugs, sacituzumab govitecan and cetuximab, can shrink tumors in people with advanced head and neck cancer that has returned or spread after initial treatment. About 40 adults whose cancer worsened after first-line therapy will receive the c…

This study looks at whether people with early-stage oral or throat cancer can have surgery to remove the tumor and check lymph nodes without staying overnight in the hospital. It aims to see if this outpatient approach is safe and acceptable. About 25 adults with small, operable …

This study tests giving chemotherapy and immunotherapy before standard surgery for head and neck cancer. The goal is to shrink tumors enough so that surgeons can perform less extensive, function-preserving operations, reducing damage to swallowing, speech, and vision. The trial e…

This study tests a new surgical technique that uses skin from the groin area (external pudendal flap) to rebuild the mouth or throat after cancer removal. The goal is to see if this method is safe and causes fewer problems at the donor site compared to standard flaps. Up to 40 ad…

This study tests a program called ENDURE that helps head and neck cancer patients start radiation therapy within 6 weeks after surgery, as guidelines recommend. About 532 adults with certain types of head and neck cancer will take part. The program uses patient navigators to guid…

This study aims to see if researchers can create a personalized tumor model from a biopsy that predicts how a patient's oral cancer will respond to the immunotherapy drug pembrolizumab before surgery. About 20 adults with advanced oral cancer will participate. The goal is to find…

This study is creating a large, long-term database of medical information and biological samples from people with many types of cancer, those at high risk, and healthy volunteers. Researchers will use this resource to study what causes cancer, how it progresses, and how to better…

This study tests whether using 3D computer models and printed surgical guides leads to better bone healing than standard free-hand surgery for people needing jaw reconstruction after oral cancer. About 420 adults will be randomly assigned to one of the two methods. The main goal …

This study looks at how cancer and its treatments change taste and smell, and how that leads to poor nutrition. Researchers will follow 306 people newly diagnosed with mouth, throat, colon, or liver cancer. The goal is to better understand these sensory changes so doctors can spo…