OPIOID ANALGESIA

This study tests whether an ultrasound-guided nerve block, given before lumbar spine surgery, can reduce pain and the need for opioid painkillers afterward. Fifty adults scheduled for back surgery will be randomly assigned to receive either the nerve block plus standard pain mana…

This study tests whether a 7-day buprenorphine skin patch can safely control pain after ankle fracture surgery and reduce the need for addictive opioids. About 100 adults who have never taken opioids before will receive either the real patch or a placebo, along with standard pain…

This study tests a new painkiller called Anrikefon in 204 adults having eye surgery under general anesthesia. Researchers want to see if it controls pain as well as the standard drug nalbuphine, but with fewer side effects like drowsiness. Participants get one dose during surgery…

This study tests whether a continuous infusion of nefopam, a non-opioid painkiller, can reduce opioid use and pain after pancreatoduodenectomy (a major pancreatic surgery). About 93 adults will be randomly assigned to receive nefopam, lidocaine, or standard epidural pain relief. …

This study looks at how painkillers and sedatives are given to patients on ECMO, a life-support machine for severe heart or lung failure. Researchers will first review current sedation practices in UK hospitals, then work with patients, families, and staff to design a safer sedat…