OBESITY & OVERWEIGHT

This study gives overweight teens ages 12-17 free weekly produce from a local farm for 8 weeks, along with educational videos. Researchers want to see if this program is practical and if it increases fruit and vegetable intake, improves blood pressure, and helps with weight. Fift…

This study tests whether eating freeze-dried grape powder every day for 4 weeks can improve gut bacteria, reduce inflammation, and lower stress in adults with obesity. Fifty participants aged 30-45 will be randomly assigned to receive grape powder or a placebo, then switch after …

This study compares a standard smartphone app with a more interactive version to see which helps people better follow their care plan after weight-loss surgery. About 200 adults having bariatric surgery will participate. Researchers will measure weight loss, quality of life, and …

This study tests a weekly injection called UBT251 in 180 overweight or obese adults with chronic kidney disease. The goal is to see if it can reduce protein in the urine (a sign of kidney damage) and help with weight control. Participants will receive either the drug or a placebo…

This early-stage trial tests a new drug called RN3161, alone and combined with the weight-loss drug tirzepatide, in 104 adults with overweight or obesity. The main goals are to check safety and how the body handles the drug. Researchers will also measure weight changes. The study…

This study looks at whether adding GLP-1 weight-loss drugs to cognitive behavioral therapy helps adults with severe obesity and binge eating disorder. About 80 participants will either take a GLP-1 drug or not, while both groups attend therapy sessions. Researchers will track cha…

This study tests a mobile app called FoodTraining that trains people to resist food cues. About 113 adults with obesity, bulimia, or binge-eating disorder will use the app for 4 weeks alongside their usual treatment. Researchers will measure changes in emotional eating and uncont…

This study compares two methods of breathing trials for overweight and obese ICU patients before removing their breathing tube. One hundred adults with a BMI of 25 or higher who have been on a ventilator for over 24 hours will be randomly assigned to either pressure support venti…

This study tests whether eating all meals within an early 8-hour window (and cutting calories by 25%) can improve blood sugar and heart health in people who are overweight and have prediabetes, type 2 diabetes, or normal blood sugar. Thirty participants will try either early or l…

This study looks at how blocking the ghrelin receptor—a key hunger signal—affects appetite in people with obesity who are already taking semaglutide (a GLP-1 drug). Researchers will give 24 participants either LEAP2 (a natural hormone that blocks ghrelin) or a placebo during two …

This study looks at how taking multiple medications (polypharmacy) affects the health of elderly people with chronic diseases like heart disease, diabetes, and high blood pressure. Researchers will survey 2000 patients aged 65 and older over two years to understand their medicati…