Can blocking a hunger receptor boost weight loss? small study investigates
NCT ID NCT07171723
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study looks at how blocking the ghrelin receptor—a key hunger signal—affects appetite in people with obesity who are already taking semaglutide (a GLP-1 drug). Researchers will give 24 participants either LEAP2 (a natural hormone that blocks ghrelin) or a placebo during two visits, then measure food intake, hunger feelings, and metabolism. The goal is not to test a new treatment, but to better understand how appetite systems work together.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- LEAP2 (a natural hormone that blocks hunger signals)
- What this could lead to
- If successful, this study could help scientists understand how different appetite systems interact, potentially leading to better obesity treatments.
- What could go wrong
- This is a very small, early-phase trial (24 people) that is not testing a new treatment—it is only measuring short-term effects. Results may not lead to any new therapy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Center for Clinical Metabolic Research, Gentofte Hospital
RECRUITINGHellerup, 2900, Denmark
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