NEUROINFLAMMATION

This study tested a new MRI contrast agent called RVP-001, made with manganese instead of gadolinium, in 18 adults with known brain lesions (like tumors or multiple sclerosis). The goal was to see if it is safe and can detect lesions as well as current gadolinium-based dyes. Each…

This pilot study tested whether adding structured supportive psychotherapy to the antipsychotic risperidone could improve cognitive function and reduce inflammation in 44 hospitalized adults with schizophrenia. Participants received either risperidone plus 12 weekly talk therapy …

This study tested whether adding ashwagandha extract to standard schizophrenia medication (risperidone) could reduce inflammation and improve symptoms. 80 male patients took part. Researchers measured changes in a blood marker for inflammation (IL-1β) and used a standard symptom …

This study tested whether celecoxib (Celebrex), an anti-inflammatory drug, can reduce brain inflammation in people with major depression. 41 adults with depression received 400 mg of celecoxib daily for 8 weeks. Researchers used PET scans to measure inflammation before and after …

This study tested whether taking royal jelly (a bee product) as a daily supplement for 4 weeks could improve memory and thinking in healthy adults aged 55-70. Researchers measured cognitive test scores and blood markers of inflammation. The goal was to see if royal jelly's anti-i…

This study tested whether giving ibuprofen before hernia surgery helps older adults avoid confusion and memory problems after the operation. Seventy-six men aged 65-84 received either ibuprofen or a placebo before surgery. Researchers measured their thinking skills, pain levels, …

This study looked at 40 people having both wisdom teeth removed, two weeks apart. Researchers measured two natural chemicals in the blood—serotonin and kynurenic acid—before and after surgery to see if they relate to pain and anxiety. The goal was to better understand how these c…