NECROTIZING ENTEROCOLITIS

This early-phase study tests whether an oral supplement called L-Citrulline is safe for preterm babies born at or before 30 weeks who have lung problems (BPD) or a serious gut condition (NEC). The goal is to see if raising low levels of a natural substance in the blood can reduce…

This study tests a new drug called ST266 in premature infants with necrotizing enterocolitis (NEC), a severe gut infection. The trial will include 36 babies and aims to see if the drug is safe and tolerable at two different doses. Researchers will also look for early signs that i…

This study tests whether early physiotherapy, taught to parents, can improve movement and development in babies at risk for problems like cerebral palsy. Fifty infants from the NICU will be randomly assigned to get either the special program or standard care. Researchers will mea…

This large international trial tests whether temporarily stopping milk feeds around the time of a blood transfusion can prevent necrotizing enterocolitis (NEC), a severe gut infection, in very premature babies (born before 30 weeks). Over 4,000 infants in Canada and the UK will b…

This study looks at how the intestines develop in premature and full-term babies up to 2 years old. Researchers will collect tissue, blood, and stool samples from infants already having intestinal surgery or scopes. The goal is to better understand normal development and diseases…

This study is looking at whether small differences in certain genes make very low birth-weight babies more likely to develop chronic lung disease and other complications of prematurity. Researchers will compare the genes of 1,100 infants who develop these conditions with those wh…