MYOCARDIAL ISCHEMIA

This study tests two different drug-coated stents (SUPRAFLEX Cruz and SYNERGY) in about 1,550 people with severe blockages in all three main heart arteries. Participants receive a stent procedure plus modern heart care like cholesterol-lowering drugs. The goal is to see which ste…

This study tests a simple, low-cost method to reduce heart damage during non-cardiac surgery in high-risk patients. Before surgery, a blood-pressure cuff is inflated on the upper arm for 5 minutes, then deflated for 5 minutes, repeated a few times. The goal is to see if this brie…

This study was designed to test the safety of injecting a gene therapy called VM202 directly into the heart muscle of people with severe, long-term chest pain due to blocked arteries. The treatment aimed to help grow new blood vessels to improve blood flow. However, the study was…

This study tests a new PET heart scan that uses 10 to 100 times less radiation than current methods. It involves 200 adults with known or suspected heart artery disease. Participants get a tiny dose of a radioactive tracer and are scanned for up to 3 hours to see if the images ar…

This study compares a new heart attack diagnosis method that focuses on whether an artery is fully blocked (occlusion) versus the standard method based on ECG changes. Researchers will track 6,000 adults with suspected heart attacks to see if the new approach better predicts arte…

This study with 2000 adults aged 30-75 who have new, stable chest pain tests whether using personalized risk models can safely reduce the number of diagnostic heart tests. Researchers will also evaluate a new laser technique that measures blood flow in the hand's tiny vessels, wh…

This study tests whether ivabradine, a drug that slows the heart rate, can prevent heart injury in adults aged 45 and older who are at risk during noncardiac surgery. About 2,146 participants will receive either ivabradine or a placebo before and after surgery. The goal is to see…

This study looks at why some women with heart disease symptoms have clear main arteries but still experience chest pain or stress test issues. Researchers think tiny heart vessels or blood clotting problems may be the cause. The goal is to better understand these issues by measur…

This study follows over 5,000 people with stable heart disease for up to 10 years to compare two treatment approaches: an early invasive strategy (procedures like stents or bypass surgery plus medications) versus medications alone. The goal is to see which strategy leads to fewer…

This study looks at how doctors use a special camera called OCT to see inside heart arteries during a procedure to place stents (small mesh tubes). The goal is to see if following a specific guide (the MLD-MAX algorithm) helps improve how well the stent opens the artery. About 20…

This study looks at whether combining stress echocardiography results with routine health information (like blood pressure and diabetes) can better predict major heart problems like heart attacks or strokes. Researchers will use artificial intelligence to analyze data from about …