MORTALITY

This study in Guinea-Bissau tests a new policy: giving the measles vaccine to all children up to 35 months old, instead of only those under 12 months. Researchers think the vaccine may have extra health benefits beyond preventing measles, possibly cutting deaths by half. Around 3…

This study tested whether a physical activity program delivered by mail and website could improve the health of nearly 50,000 older women already in the Women's Health Initiative. The program included aerobic, balance, strength, and flexibility exercises, and encouraged reducing …

This study tested whether giving the oral polio vaccine (OPV) to adults over 50 in Guinea-Bissau could reduce their risk of getting sick or dying from COVID-19 and other infections. Researchers enrolled about 3,700 people and gave half the vaccine plus COVID-19 advice, while the …

This study tested whether adding the drug bezlotoxumab to standard treatment could prevent serious outcomes in people with a severe C. diff infection. Researchers used a special score to identify 44 high-risk patients. The goal was to see if the drug reduced organ failure, infect…

This completed study looked at 172 patients who received either a new-generation biological aortic valve or a traditional one during heart surgery. Researchers tracked survival and valve function over five years to see how the newer valves compare. The goal is to provide real-wor…

This study aims to create a simple bedside tool that helps doctors quickly identify motorcycle accident victims with chest injuries who are at high risk of dying. Researchers will analyze data from 1250 patients to build and test the tool, focusing on factors like helmet use and …

This study tested if a system that ranks emergency surgeries by urgency leads to better results. Researchers tracked 756 adults who had non-cardiac emergency surgery. They wanted to see if delays beyond the recommended time for each urgency level increased complications or deaths…

This study looked back at the medical records of 137 severely injured trauma patients who needed large blood transfusions between 2020 and 2025. Researchers analyzed how different transfusion strategies, such as balanced ratios and whole blood use, affected 30-day survival and ot…

This study looked at whether common early warning scores can predict which older patients (65+) are at risk of dying within 28 days after visiting the emergency room. Researchers tracked over 2,700 patients, recording vital signs, lab results, and frailty. The goal was to see whi…

This study looked at nearly 30,000 older adults (65+) having non-cardiac surgery to see if levels of homocysteine, a natural amino acid, could predict serious complications like kidney injury or death. Researchers measured homocysteine before and after surgery. The goal was to se…

This study looked at over 315,000 very old patients (80+) admitted to Swedish ICUs. It found that the longer a patient stayed in a regular hospital ward before being moved to the ICU, the higher their risk of dying within 30 days. The research highlights the need for careful deci…

This study looked at 260 adults in the intensive care unit (ICU) who needed oxygen therapy. Researchers found that about 60% of patients had too much oxygen in their blood (hyperoxemia). Those with hyperoxemia had longer stays in the ICU and hospital, and a much higher chance of …

This study looked at whether a frailty index (a score based on health problems) can predict the risk of dying within one year for older adults (65+) who receive hospital-level care at home. Researchers followed 2,610 patients and compared the frailty score to another common measu…

This study examined whether routine blood tests (like PCT, CRP, and lactate) can help predict the risk of death within 28 days in adults admitted to the ICU with suspected sepsis. Researchers reviewed medical records of 250 patients to find links between these biomarkers and surv…

This pilot study looked at whether giving extra oxygen during heart surgery (when a heart-lung machine is used) affects kidney function afterward. 104 adults having elective heart surgery were randomly assigned to receive either high or normal oxygen levels. The main goal was to …

This study reviewed medical records of 901 infants who had surgery for aortic coarctation (a narrowed aorta) before age one. Researchers wanted to find out how many later developed high blood pressure or re-narrowing of the aorta. The goal is to better understand these risks and …

This study compared 50,000 living kidney donors to similar healthy non-donors to see if donating a kidney raises the long-term risk of heart attack, stroke, or death. Researchers looked at health records from 1992 to 2024 in three Canadian provinces. The goal is to help doctors a…

This study looked at 1,000 people who had a severe type of heart attack (STEMI). Researchers checked two simple nutrition scores (CONUT and PNI) based on routine blood tests taken when patients arrived at the hospital. The goal was to see if these scores could predict who was mor…

This study looked at 600 COVID-19 patients with severe breathing problems who were treated with high-flow nasal oxygen and asked to lie face-down (awake prone position). The goal was to see if this combination reduced the need for a breathing tube and lowered death rates. Researc…

This study looked at older adults (65+) having surgery to see if delirium (sudden confusion after surgery) makes frailty worse and how that affects their risk of dying within a year. Researchers followed over 6,000 patients, checking frailty before and one month after surgery, an…

This study tested whether using a video to measure capillary refill time (how fast skin color returns after pressure) is more consistent than the usual visual method. Researchers compared measurements taken by different doctors in 59 ICU patients. The goal was to see if the video…

This completed study reviewed medical records of 1,250 advanced cancer patients who visited the emergency department. Researchers looked at factors like age, tumor type, and blood test results to see which patients were at higher risk of dying within 90 days. The goal is to help …