MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE
Clinical trials for MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE explained in plain language.
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Supercharged immune cells take aim at myeloma
Disease control OngoingThis early-stage trial tests whether specially trained immune cells can safely target and attack multiple myeloma, as well as its early forms MGUS and smoldering myeloma. Up to 36 participants will receive two infusions of their own T cells that have been engineered to recognize …
Matched conditions: MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE
Phase: PHASE1 • Sponsor: Baylor College of Medicine • Aim: Disease control
Last updated Aug 07, 2026 00:00 UTC
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Promising nerve pain drug trial for MGUS patients withdrawn before start
Disease control TerminatedThis study aimed to test if daratumumab could improve nerve damage (peripheral neuropathy) in people with a blood condition called MGUS. Participants would have received weekly injections for two months, then biweekly for four more months. However, the trial was withdrawn before …
Matched conditions: MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE
Phase: PHASE2 • Sponsor: Georgetown University • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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New blood test screening targets hidden cancer in black communities
Diagnosis OngoingThis study is testing a blood screening program to find multiple myeloma and its early stages (MGUS and smoldering myeloma) in Black adults aged 50 and older. Participants get a simple blood test and fill out questionnaires about their experience and knowledge of the disease. Tho…
Matched conditions: MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE
Phase: NA • Sponsor: Case Comprehensive Cancer Center • Aim: Diagnosis
Last updated Jun 27, 2026 14:02 UTC
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Old diabetes drug, new hope: could metformin stop myeloma before it starts?
Prevention OngoingThis phase 2 trial is testing whether metformin, a widely used diabetes medication, can prevent progression to multiple myeloma in 60 people with early blood disorders called MGUS and smoldering multiple myeloma. Participants receive either extended-release metformin or a placebo…
Matched conditions: MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE
Phase: PHASE2 • Sponsor: Dana-Farber Cancer Institute • Aim: Prevention
Last updated Jun 27, 2026 09:03 UTC
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Could a Plant-Based diet stop a blood cancer before it starts?
Prevention OngoingThis study tests whether a plant-based diet is practical for overweight people with MGUS or smoldering multiple myeloma, conditions that can lead to multiple myeloma. For 12 weeks, 23 participants receive two pre-made plant-based meals daily. Researchers track weight loss and die…
Matched conditions: MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE
Phase: NA • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Prevention
Last updated Jun 26, 2026 15:05 UTC
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Massive MGUS screening aims to unlock early myeloma clues
Knowledge-focused ENROLLING_BY_INVITATIONThis study screens 1000 adults aged 40 and older for MGUS, a condition with an abnormal blood protein that can sometimes lead to multiple myeloma. Researchers want to learn about genetic and immune factors behind MGUS, especially in diverse populations. The goal is to improve ear…
Matched conditions: MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Aug 13, 2026 00:00 UTC
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Can we predict myeloma before it starts? new study aims to find out
Knowledge-focused ENROLLING_BY_INVITATIONThe PROMISE study is enrolling 30,000 people at high risk for multiple myeloma, including African Americans and those with a family history of blood cancers. Participants provide blood samples so researchers can track changes over time and identify who progresses to myeloma. The …
Matched conditions: MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE
Sponsor: Dana-Farber Cancer Institute • Aim: Knowledge-focused
Last updated Aug 02, 2026 00:00 UTC
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Scientists launch tissue bank to unlock secrets of rare blood cancers
Knowledge-focused OngoingThis study collects bone marrow and blood samples, along with medical history, from people with multiple myeloma, Waldenstrom macroglobulinemia, and related disorders. The samples are stored in a tissue bank for future research to understand what causes these cancers, how they pr…
Matched conditions: MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE
Sponsor: Dana-Farber Cancer Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Iceland launches massive screening study for early cancer detection
Knowledge-focused OngoingThis study is screening over 80,000 people in Iceland to see if early detection of a condition called MGUS can prevent or improve outcomes for multiple myeloma, a type of blood cancer. Participants are randomly assigned to routine care or closer monitoring. The goal is to compare…
Matched conditions: MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE
Phase: NA • Sponsor: University of Iceland • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC