METASTATIC UVEAL MELANOMA

This study is testing whether combining two drugs, binimetinib and belinostat, can shrink tumors or stop them from growing in adults with metastatic uveal melanoma, a rare and aggressive cancer that starts in the eye. The goal is to see if this combination is effective at control…

This early-stage trial is testing a new way to give an immunotherapy drug called nivolumab to patients with melanoma or lung cancer that has spread to the membranes surrounding the brain and spinal cord. The goal is to see if giving the drug directly into the spinal fluid, along …

This early-stage trial is testing four different combinations of experimental drugs with existing cancer medications for people with metastatic solid tumors. The study aims to find safe doses and see if these combinations can shrink tumors in seven specific cancer types. It's des…

This study is testing whether a combination of two existing cancer drugs, pembrolizumab and lenvatinib, can help control metastatic uveal melanoma, a rare and aggressive cancer that starts in the eye. It will enroll about 51 patients into two groups based on whether they have had…

This study is testing whether a pill called vorinostat can help control a rare and aggressive eye cancer that has spread to other parts of the body. It will involve about 40 adults with metastatic uveal melanoma. The main goal is to see if the treatment shrinks tumors and how wel…

This clinical trial is testing whether a new two-drug combination (IDE196 plus crizotinib) works better than current standard treatments for metastatic uveal melanoma, a rare but aggressive eye cancer that has spread. The study will enroll 420 patients who are HLA-A2 negative and…