New drug cocktail aims to fight deadly eye cancer
NCT ID NCT05987332
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a combination of two oral drugs, darovasertib and crizotinib, against standard treatments (immunotherapy or chemotherapy) in 420 people with a specific type of advanced eye melanoma that has spread. Participants must have a certain genetic marker (HLA-A2 negative) and not have had prior systemic therapy. The goal is to see if the new combo improves how long people live without their cancer growing or overall survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Darovasertib (IDE196) plus crizotinib
What this could lead to
If successful, this combination could become a new first-line treatment option for people with a specific type of metastatic eye melanoma, potentially improving survival.
What could go wrong
This is an early-to-mid stage trial (Phase 2/3) with no results yet. The combination may not work better than existing therapies, and side effects from the drugs could be significant.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AOUS Policlinico Le Scotte
Siena, 53100, Italy
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Alfred Health
Melbourne, Victoria, 3168, Australia
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Algemene Medische Oncologie UZ
Leuven, 3000, Belgium
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BC Cancer Agency
Vancouver, British Columbia, V5Z4C2, Canada
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California Pacific Medical Center (CPMC)
San Francisco, California, 94115, United States
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Catalan Institute of Oncology
L'Hospitalet de Llobregat, 8908, Spain
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Centre Hospitalier de l'Universite de Montreal- CHUM
Montreal, Quebec, H2X 0C1, Canada
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Charité - Universitätsmedizin Berlin
Berlin, 12203, Germany
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Cliniques Universitaires Saint Luc
Brussels, 1200, Belgium
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Cross Cancer Institute, University of Alberta
Edmonton, Alberta, T6G 1Z2, Canada
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Dermatologische Klinik, USZ Flughafen Geschoss 7 - Klinische Forschung
Zurich, 8058, Switzerland
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Duke University Health System
Durham, North Carolina, 27710, United States
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Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, 20133, Italy
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Fondazione Policlinico Gemelli IRCCS
Roma, 00168, Italy
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Hadassah Medical Center
Jerusalem, 91120, Israel
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Honor Health
Scottsdale, Arizona, 85258, United States
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Hospital Clínico Universitario de Santiago de Compostela
Santiago de Compostela, 15706, Spain
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Hospital General Universitario Valencia
Valencia, 46014, Spain
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Hospital Universitario La Paz
Madrid, 28046, Spain
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Hospital Universitario Virgen Macarena
Seville, 41009, Spain
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Houston Methodist Cancer Center
Houston, Texas, 77030, United States
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Institut Curie
Paris, 75005, France
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Istituto Nazionale dei Tumori Fondazione Pascale
Naples, 80131, Italy
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LUMC (Leids Universitair Medisch Centrum)
Leiden, 2333 ZA, Netherlands
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Minnesota Oncology Hematology, P.A.
Burnsville, Minnesota, 55337, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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Moores Cancer Center
La Jolla, California, 92093, United States
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Mount Vernon Cancer Centre East & North Herts NHS Trust
Northwood, HA6 2RN, United Kingdom
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NCT Heidelberg
Heidelberg, Baden-Wurttemberg, 69120, Germany
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Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie Państwowy Instytut Badawczy
Warsaw, 02-781, Poland
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Northside Hospital Atlanta
Atlanta, Georgia, 30342, United States
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Northwell Health
Manhasset, New York, 11030, United States
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Ośrodek Badań Klinicznych Wczesnych Faz, Uniwersyteckie Centrum Kliniczne w Gdańsku
Gdansk, 80-214, Poland
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Peter MacCallum Cancer Centre
Melbourne, Victoria, 3000, Australia
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Princess Alexander Hospital
Brisbane, Queensland, 4102, Australia
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Princess Margaret Cancer Centre
Toronto, Ontario, M5G 2M9, Canada
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Queen Elizabeth Hospital
Adelaide, Australia
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Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
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SCRI Oncology Partners
Nashville, Tennessee, 37203, United States
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SCRI at HealthONE
Denver, Colorado, 80218, United States
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Sheba Medical Center
Ramat Gan, 52621, Israel
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Sir Charles Gairdner Hospital
Perth, Washington, 6009, Australia
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Texas Oncology- DFW
Dallas, Texas, 75246, United States
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The Angeles Clinic and Research Institute
Los Angeles, California, 90025, United States
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The Beatson West of Scotland Cancer Centre
Glasgow, G12 0YN, United Kingdom
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The Cancer and Hematology Centers
Grand Rapids, Michigan, 49546, United States
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The Clatterbridge Cancer Centre NHS Foundation Trust
Metropolitan Borough of Wirral, CH63 4JY, United Kingdom
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The Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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The Leon Berard Center
Lyon, France
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Thomas Jefferson University
Philadelphia, Pennsylvania, 19107, United States
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UCLA Medical Center
Los Angeles, California, 90024, United States
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UT Southwestern Medical Center
Dallas, Texas, 75390, United States
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University of California San Francisco
San Francisco, California, 94143, United States
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University of Cincinnati
Cincinnati, Ohio, 45267, United States
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University of Colorado Cancer Center
Aurora, Colorado, 80045, United States
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University of Iowa
Iowa City, Iowa, 52242, United States
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University of Miami Sylvester Comprehensive Cancer Center
Miami, Florida, 33136, United States
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University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15232, United States
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Universitätsklinikum Carl Gustav Carus Dresden
Dresden, Saxony, 1307, Germany
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Universitätsklinikum Essen (AöR)
Essen, North Rhine-Westphalia, 45147, Germany
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Universitätsklinikum Köln
Cologne, North Rhine-Westphalia, 50937, Germany
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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Westmead Hospital
Sydney, New South Wales, 2145, Australia