MELANOMA STAGE IV
Clinical trials for MELANOMA STAGE IV explained in plain language.
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New drug combo aims to unleash immune system against melanoma
Disease control OngoingThis early-phase study tests a new drug, SX-682, combined with the immunotherapy pembrolizumab in people with advanced melanoma. The goal is to see if SX-682 can block cancer's ability to hide from the immune system, making the treatment more effective. About 77 participants will…
Matched conditions: MELANOMA STAGE IV
Phase: PHASE1 • Sponsor: Syntrix Biosystems, Inc. • Aim: Disease control
Last updated Jun 17, 2026 01:41 UTC
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New combo shows promise against tough skin cancer
Disease control OngoingThis study tests a new drug, EVX-01, combined with the standard immunotherapy pembrolizumab in 17 adults with advanced melanoma that cannot be removed by surgery. The goal is to see if adding EVX-01 improves tumor shrinkage compared to historical data with pembrolizumab alone. Pa…
Matched conditions: MELANOMA STAGE IV
Phase: PHASE2 • Sponsor: Evaxion Biotech A/S • Aim: Disease control
Last updated Jun 17, 2026 01:29 UTC
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New hope for patients with rare brain lining cancer spread
Disease control OngoingThis early-phase study tests a new way to give immunotherapy drugs (nivolumab and ipilimumab) for patients with lung cancer or melanoma that has spread to the lining of the brain and spinal cord (leptomeningeal metastases). The drugs are given both directly into the spinal fluid …
Matched conditions: MELANOMA STAGE IV
Phase: PHASE1 • Sponsor: University of Zurich • Aim: Disease control
Last updated Jun 16, 2026 12:49 UTC
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New vaccine combo shows promise in advanced skin cancer trial
Disease control OngoingThis study tests two experimental cancer vaccines, SCIB1 and iSCIB1+, given alongside standard immunotherapy drugs (nivolumab with ipilimumab or pembrolizumab) for people with advanced melanoma that cannot be removed by surgery. The goal is to see if adding the vaccines is safe a…
Matched conditions: MELANOMA STAGE IV
Phase: PHASE2 • Sponsor: Scancell Ltd • Aim: Disease control
Last updated Jun 15, 2026 19:09 UTC
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Can a drug for arthritis beat steroids for immunotherapy side effects?
Disease control OngoingThis study compares infliximab, a drug used for arthritis, to standard steroids for treating colitis (inflammation of the colon) caused by immunotherapy in people with advanced skin cancer. About 42 participants will receive either infliximab or steroids to see which leads to fas…
Matched conditions: MELANOMA STAGE IV
Phase: PHASE2 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jun 15, 2026 19:02 UTC
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Could a Two-Drug punch shrink melanoma before surgery?
Disease control OngoingThis study tests whether giving a combination of two immunotherapy drugs (dostarlimab and cobolimab) before surgery works better than one drug alone for people with stage III or IV melanoma that can be removed. The goal is to see if the combo can shrink or kill more of the tumor …
Matched conditions: MELANOMA STAGE IV
Phase: PHASE2 • Sponsor: Diwakar Davar • Aim: Disease control
Last updated Jun 10, 2026 13:25 UTC
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New drug ST101 tested in patients with advanced cancers
Disease control OngoingThis study tests a new drug called ST101 in people with advanced solid tumors that cannot be removed by surgery or have spread. The goal is to find a safe dose and see if the drug can shrink tumors. About 125 adults with cancers like glioblastoma, melanoma, breast, or prostate ca…
Matched conditions: MELANOMA STAGE IV
Phase: PHASE1, PHASE2 • Sponsor: Sapience Therapeutics • Aim: Disease control
Last updated May 26, 2026 12:11 UTC
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Melanoma survivors: how does immunotherapy affect your daily life?
Knowledge-focused OngoingThis study looks at side effects and overall well-being in people who have had melanoma and are now getting immunotherapy to prevent the cancer from coming back. Researchers will track side effects and ask participants about their quality of life, depression, and fatigue for up t…
Matched conditions: MELANOMA STAGE IV
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Jun 03, 2026 12:08 UTC