MALIGNANT SOLID TUMORS

This phase 2 study tests asciminib, a daily pill, in 40 adults with chronic myeloid leukemia whose first treatment with a TKI drug didn't work or caused side effects. Participants take asciminib for up to 2 years. The main goal is to see how many achieve a major molecular respons…

This study tests a new drug called TAK-505 in adults with advanced solid tumors that cannot be removed by surgery. The main goals are to check safety, find the best dose, and see if the drug can shrink or slow cancer growth. About 151 people with certain cancers, such as stomach,…

This study tests a new drug called SHR-4849 combined with other cancer medicines in people with advanced solid tumors. The goal is to see if the combination is safe and can shrink tumors. About 120 adults aged 18 to 75 with measurable tumors and good organ function will take part…

This study is testing an experimental drug called SHR-7787 combined with other anti-cancer medicines in 400 people with advanced solid tumors that cannot be removed by surgery. The goal is to find safe doses and see if the combination can shrink tumors or slow cancer growth. Part…

This study tests an experimental drug called SHR-1681 in 300 people with advanced solid tumors that have not responded to standard treatments. The goal is to find a safe dose and see if the drug can shrink tumors. It is an early-stage trial, so the main focus is on safety and how…

This study is testing whether a new MRI technique using a substance called hyperpolarized pyruvate gives consistent results in people with solid tumors. About 109 participants will have two special MRI scans to see if the images are reproducible. The goal is to improve how doctor…

This study is collecting medical information and biological samples from up to 10,000 people with rare solid tumors, their relatives, and those with genetic mutations that raise cancer risk. Researchers hope to learn how these tumors develop and change over time. The goal is to i…