LYMPHOMA, B-CELL

This study tests a new cell therapy called ronde-cel that targets two proteins (CD19 and CD20) on lymphoma cells, compared to standard CAR T-cell therapy that targets only one. About 400 adults with large B-cell lymphoma that came back or didn't respond to first treatment will ta…

This early-phase study tests two experimental drugs (iberdomide and CC-99282) added to standard chemotherapy (R-CHOP) for people with untreated aggressive B-cell lymphoma. About 224 adults will take part to find the safest dose and see if the combination helps shrink tumors. The …

This early-phase trial tests a new drug called BTM-3566 in 24 adults whose B-cell lymphoma has returned or not responded to treatment. The main goals are to check safety, find the right dose, and see if the drug can slow or stop the cancer. Participants take the drug in 14-day cy…

This study tests a new treatment called JNJ-90014496 (prizlo-cel) for adults with B-cell non-Hodgkin lymphoma that has come back or not responded to other treatments. The therapy uses a patient's own immune cells, which are modified in a lab to better recognize and attack cancer …

This study tests a new drug called STP938 in adults with B-cell or T-cell lymphoma that has returned or not responded to at least two prior treatments. The goal is to find a safe dose and see if the drug can shrink tumors. About 180 participants will receive STP938 alone, with th…

This early-stage study tests a new treatment called UB-VV111 given with rapamycin for people with relapsed or refractory large B-cell lymphoma or chronic lymphocytic leukemia. The goal is to check safety and see if the treatment can shrink tumors. About 106 adults will take part.

This study looks at whether adding early palliative care to usual treatment helps people with multiple myeloma or aggressive lymphoma feel better. About 144 patients and their caregivers will either get early palliative care or standard care alone. Researchers will track quality …

This study looks at whether CAR-T cell therapy, a new immune treatment for blood cancers, can cause early heart problems. Researchers will use ultrasound to check the heart function of 60 patients before and within a few days after treatment. The goal is to find out how often the…

This study is for people newly diagnosed with a type of lymphoma called DLBCL. Researchers want to see if a blood test that tracks tumor DNA can help decide who can safely stop chemotherapy early. About 40 participants will get standard treatment, and those whose blood test shows…

This study is developing and testing a communication training program called Hematolo-GIST for doctors who treat large B-cell lymphoma. The goal is to help doctors talk with patients about their diagnosis and plan future care. About 48 people (doctors and patients) will take part…

This study watches how older patients (60+) with certain blood cancers handle standard CAR T therapy and how it changes their quality of life. No extra treatment is given—just regular care and check-ins. The goal is to see if patients can complete all planned visits before their …

This study looks at why some families have more blood cancers like lymphoma, leukemia, and myeloma. Researchers will study the genes and environment of 3000 people who have at least two living relatives with these cancers. The goal is to find inherited factors that raise risk, no…