New combo therapy targets hard-to-treat blood cancers in early trial

NCT ID NCT06528301

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tests a new treatment called UB-VV111 given with rapamycin for people with certain types of blood cancer (large B-cell lymphoma or chronic lymphocytic leukemia) that have come back or stopped responding to other treatments. The main goal is to check the safety of the combination and see how well it shrinks tumors. About 106 adults will take part.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia B-cell neoplasm diffuse large B-cell lymphoma large B-cell lymphoma lymphoma lymphoma, non-Hodgkin, familial non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • City of Hope

    NOT_YET_RECRUITING

    Duarte, California, 91010, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Fred Hutch Cancer Center

    RECRUITING

    Seattle, Washington, 98109, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Royal North Shore Hospital

    RECRUITING

    Saint Leonards, New South Wales, 2065, Australia

    Contact Phone: •••-•••-••••

    Contact

  • St. Vincent's Hospital Melbourne

    RECRUITING

    Fitzroy, Victoria, 3065, Australia

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • The David and Etta Jonas Center for Cellular Therapy

    RECRUITING

    Chicago, Illinois, 60637, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Cincinnatti Medical Center

    RECRUITING

    Cincinnati, Ohio, 45219, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Nebraska Medical Center

    RECRUITING

    Omaha, Nebraska, 68198-6814, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Washington University School of Medicine/Siteman Cancer Center

    RECRUITING

    St Louis, Missouri, 63110, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact