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New combo therapy targets hard-to-treat blood cancers in early trial

NCT ID NCT06528301

Recruiting now Disease control Sponsor: Umoja Biopharma Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tests a new treatment called UB-VV111 given with rapamycin for people with certain types of blood cancer (large B-cell lymphoma or chronic lymphocytic leukemia) that have come back or stopped responding to other treatments. The main goal is to check the safety of the combination and see how well it shrinks tumors. About 106 adults will take part.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia B-cell neoplasm diffuse large B-cell lymphoma large B-cell lymphoma lymphoma lymphoma, non-Hodgkin, familial non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) LYMPHOMA, B-CELL LYMPHOMA, LARGE B-CELL, DIFFUSE (DLBCL) LYMPHOMA, NON-HODGKIN (NHL)

Contacts and locations

Locations

  • City of Hope

    NOT_YET_RECRUITING

    Duarte, California, 91010, United States

  • Fred Hutch Cancer Center

    RECRUITING

    Seattle, Washington, 98109, United States

  • Royal North Shore Hospital

    RECRUITING

    Saint Leonards, New South Wales, 2065, Australia

  • St. Vincent's Hospital Melbourne

    RECRUITING

    Fitzroy, Victoria, 3065, Australia

  • The David and Etta Jonas Center for Cellular Therapy

    RECRUITING

    Chicago, Illinois, 60637, United States

    Contact Email: •••••@•••••

  • University of Cincinnatti Medical Center

    RECRUITING

    Cincinnati, Ohio, 45219, United States

  • University of Nebraska Medical Center

    RECRUITING

    Omaha, Nebraska, 68198-6814, United States

  • Washington University School of Medicine/Siteman Cancer Center

    RECRUITING

    St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.