New dual-targeting CAR t therapy takes on hard-to-treat lymphoma in phase 3 trial
NCT ID NCT07188558
First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 2 times
Summary
This phase 3 trial tests a new CAR T-cell therapy called rondecabtagene autoleucel (ronde-cel) that targets two proteins (CD19 and CD20) on lymphoma cells. It is compared to standard CD19-targeting CAR T-cell therapy in 400 patients with relapsed or refractory large B-cell lymphoma. The main goal is to see if ronde-cel improves event-free survival. This is a second-line treatment for people who have already tried one prior therapy.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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AdventHealth
NOT_YET_RECRUITINGOrlando, Florida, 32804, United States
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Allegheny Health Network
NOT_YET_RECRUITINGPittsburgh, Pennsylvania, 15212, United States
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Atrium Health Wake Forest Baptist Comprehensive Cancer Center
NOT_YET_RECRUITINGWinston-Salem, North Carolina, 27157, United States
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Banner MD Anderson Cancer Center
RECRUITINGGilbert, Arizona, 85234, United States
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Cedars-Sinai Medical Center
RECRUITINGLos Angeles, California, 90048, United States
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Cleveland Clinical Taussig Cancer Center
NOT_YET_RECRUITINGCleveland, Ohio, 44195, United States
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Colorado Blood Cancer Institute
RECRUITINGDenver, Colorado, 80218, United States
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Duke Cancer Institute
RECRUITINGDurham, North Carolina, 27705, United States
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Hackensack
RECRUITINGHackensack, New Jersey, 07601, United States
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Honor Health
RECRUITINGScottsdale, Arizona, 85258, United States
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Intermountain Healthcare
RECRUITINGSalt Lake City, Utah, 84143, United States
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MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Mayo Clinic Arizona
RECRUITINGScottsdale, Arizona, 85259, United States
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Mayo Clinic Florida
RECRUITINGJacksonville, Florida, 32224, United States
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Mayo Clinic Rochester
RECRUITINGRochester, Minnesota, 55905, United States
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MedStar Georgetown University Hospital
NOT_YET_RECRUITINGWashington D.C., District of Columbia, 20007, United States
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Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
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Northside Hospital
RECRUITINGAtlanta, Georgia, 30342, United States
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Northwestern
NOT_YET_RECRUITINGChicago, Illinois, 60611, United States
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Oncology Hematology Care Clinical Trials
RECRUITINGCincinnati, Ohio, 45242, United States
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Roswell Park Comprehensive Cancer Center
RECRUITINGBuffalo, New York, 14263, United States
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SCRI Oncology Partners
RECRUITINGNashville, Tennessee, 37203, United States
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St. David's South Austin Medical Center
RECRUITINGAustin, Texas, 78704, United States
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Texas Transplant Institute
RECRUITINGSan Antonio, Texas, 78229, United States
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University of Arkansas
NOT_YET_RECRUITINGLittle Rock, Arkansas, 72205, United States
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University of California, Irvine
RECRUITINGOrange, California, 92868, United States
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University of California, Los Angeles (UCLA)
RECRUITINGLos Angeles, California, 90095, United States
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University of Chicago
RECRUITINGChicago, Illinois, 60637, United States
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University of Cincinnati
RECRUITINGCincinnati, Ohio, 45267, United States
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University of Colorado
RECRUITINGAurora, Colorado, 80045, United States
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University of Iowa
NOT_YET_RECRUITINGIowa City, Iowa, 52242, United States
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University of Kansas Cancer Center
RECRUITINGWestwood, Kansas, 66205, United States
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University of Louisville Health
RECRUITINGLouisville, Kentucky, 40202, United States
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University of Nebraska Medical Center (UNMC)
RECRUITINGOmaha, Nebraska, 68105, United States
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University of Texas Southwestern Medical Center
NOT_YET_RECRUITINGFort Worth, Texas, 76104, United States
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Virginia Oncology Associates
RECRUITINGNorfolk, Virginia, 23502, United States
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Other studies related to the condition(s) this trial covers.
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