LYME DISEASE

This study tests whether a fifth dose of Pfizer's Lyme disease vaccine (VLA15) is safe and boosts immunity in people who already received four doses. About 1,700 healthy volunteers aged 7 and older will get either the vaccine or a saltwater shot. Researchers will compare side eff…

This study tests an experimental mRNA vaccine (mRNA-1982) designed to prevent Lyme disease, which is spread by tick bites. About 350 healthy adults aged 18 to 70 will receive either the vaccine or a placebo to check for safety and immune response. The goal is to find the best dos…

This study looks at how children's immune systems react to Lyme disease to create a better diagnostic test. Current tests often miss early infections or give false positives. Researchers will study up to 502 children and track their immune responses over six months.

This study tests a pill called TP-05 (lotilaner) to see if it can prevent Lyme disease in healthy adults who are often around ticks. About 700 participants will receive either a low dose, high dose, or placebo. The main goal is to check safety and how the drug moves through the b…

This study follows 500 people with active Lyme disease to better understand the infection, its biological markers, and how the immune system responds. Participants receive standard FDA-approved treatments and undergo regular checkups, blood draws, and sometimes leukapheresis. No …

This study looks at how healthy people's skin and immune system respond to tick bites. Researchers will place clean, lab-bred ticks on volunteers' skin and take small skin samples and blood to track changes. The goal is to understand tick resistance and help design future vaccine…

This study aims to understand why some people continue to have symptoms after being treated for Lyme disease. Researchers will compare patients with chronic Lyme symptoms to healthy volunteers and other groups using blood tests, spinal taps, and brain scans. The goal is to find o…

This study is building a large registry and biorepository of 5,000 adults with various rheumatic diseases like rheumatoid arthritis, lupus, and scleroderma. Researchers at Yale University will collect medical data and biological samples over time to better understand these condit…

This study follows 40 pregnant women with Lyme disease to see how the infection might affect their baby's development. Researchers will monitor pregnancies and check infant growth, thinking, and motor skills from birth to 18 months. The goal is to learn if Lyme exposure in the wo…