LOCALLY ADVANCED UROTHELIAL CARCINOMA
Clinical trials for LOCALLY ADVANCED UROTHELIAL CARCINOMA explained in plain language.
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Personalized cancer fight: matching drugs to your Tumor's genetic fingerprint
Disease control OngoingThis study is testing whether specific genetic markers in a patient's tumor can predict if they will respond well to immunotherapy drugs. It is for people with advanced bladder cancer that has spread and has stopped responding to standard chemotherapy. Participants receive two im…
Matched conditions: LOCALLY ADVANCED UROTHELIAL CARCINOMA
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Apr 01, 2026 18:41 UTC
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Scientists test Triple-Threat attack on tough bladder cancers
Disease control OngoingThis early-stage trial is testing the safety and best dose of a three-drug combination for patients with advanced bladder cancer that has spread or cannot be removed by surgery. The treatment combines two immunotherapy drugs that help the immune system fight cancer with a third d…
Matched conditions: LOCALLY ADVANCED UROTHELIAL CARCINOMA
Phase: PHASE1 • Sponsor: University of Utah • Aim: Disease control
Last updated Apr 01, 2026 18:41 UTC
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Heart drug joins fight against bladder cancer
Disease control OngoingThis study is testing if adding a common, low-cost blood pressure medication called propranolol to standard immunotherapy helps people with advanced bladder cancer. Six participants will receive either immunotherapy alone or immunotherapy plus propranolol. The main goal is to see…
Matched conditions: LOCALLY ADVANCED UROTHELIAL CARCINOMA
Phase: PHASE2 • Sponsor: Emory University • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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Cancer trial asks: can patients stop treatment sooner and stay well?
Disease control OngoingThis study is for people with advanced bladder cancer who have already had about a year of immunotherapy. It compares two approaches: continuing the immunotherapy treatment versus stopping it. The main goal is to see if stopping treatment leads to similar survival rates while pot…
Matched conditions: LOCALLY ADVANCED UROTHELIAL CARCINOMA
Phase: PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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Could less treatment be just as good? cancer trial tests new approach
Disease control OngoingThis study is testing whether giving two approved bladder cancer drugs less frequently can still control the disease while potentially reducing side effects. It involves 60 adults with advanced bladder cancer that has spread or cannot be surgically removed. The main goal is to se…
Matched conditions: LOCALLY ADVANCED UROTHELIAL CARCINOMA
Phase: PHASE2 • Sponsor: Fox Chase Cancer Center • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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New targeted drug trial aims to control advanced cancers with specific gene fault
Disease control OngoingThis study is testing an investigational drug called TYRA300 for people with advanced bladder cancer and other solid tumors that have specific changes in a gene called FGFR3. The main goals are to find a safe and effective dose and to see if the drug can shrink or control the tum…
Matched conditions: LOCALLY ADVANCED UROTHELIAL CARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: Tyra Biosciences, Inc • Aim: Disease control
Last updated Mar 30, 2026 14:32 UTC
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New drug duo tested for Tough-to-Treat bladder cancer
Disease control OngoingThis study is testing a new combination of two drugs, tazemetostat and pembrolizumab, for people with advanced bladder cancer that has spread or is resistant to standard chemotherapy. The main goals are to find the safest dose and see if the combination helps control the cancer b…
Matched conditions: LOCALLY ADVANCED UROTHELIAL CARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:31 UTC
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Trial for aggressive bladder cancer halted before starting
Disease control TerminatedThis was an early safety study for people with advanced bladder cancer that had spread. It aimed to test a combination of three drugs to see if they could control the cancer and were safe to use together. The study was withdrawn before any participants were enrolled.
Matched conditions: LOCALLY ADVANCED UROTHELIAL CARCINOMA
Phase: PHASE1 • Sponsor: Vadim S Koshkin • Aim: Disease control
Last updated Mar 30, 2026 14:30 UTC
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Scientists test new drug duo to fight tough cancers
Disease control OngoingThis early-stage study is testing a new combination of two drugs, sonidegib and pembrolizumab, for people with advanced solid tumors that have spread. The main goals are to find the safest dose of the combination and see if it helps shrink or control the cancer. The study is enro…
Matched conditions: LOCALLY ADVANCED UROTHELIAL CARCINOMA
Phase: PHASE1 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Mar 27, 2026 12:41 UTC
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Major trial tests Immune-Boosting drug to stop aggressive bladder cancer from coming back
Disease control OngoingThis large study is testing whether a drug called pembrolizumab can help prevent cancer from returning in people who have had surgery for muscle-invasive bladder or upper urinary tract cancer. After surgery, participants are randomly assigned to either receive the drug (which hel…
Matched conditions: LOCALLY ADVANCED UROTHELIAL CARCINOMA
Phase: PHASE3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 25, 2026 14:08 UTC
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New drug duo targets tough bladder cancers
Disease control OngoingThis early-stage trial is testing a combination of two targeted drugs, erdafitinib and enfortumab vedotin, for people with advanced bladder cancer that has spread and has specific genetic changes (FGFR2/3). The main goals are to find the safest and most effective dose of the drug…
Matched conditions: LOCALLY ADVANCED UROTHELIAL CARCINOMA
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 23, 2026 15:19 UTC
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New drug duo tested in fight against advanced bladder cancer
Disease control OngoingThis early-stage trial is testing the safety and initial effectiveness of combining two targeted cancer drugs for people with advanced bladder cancer that has spread or cannot be removed by surgery. The study will involve about 38 participants who have already received standard c…
Matched conditions: LOCALLY ADVANCED UROTHELIAL CARCINOMA
Phase: PHASE1, PHASE2 • Sponsor: Merck Sharp & Dohme LLC • Aim: Disease control
Last updated Mar 11, 2026 14:52 UTC