Can less be more? new study tests a gentler dosing schedule for advanced bladder cancer drug
NCT ID NCT05923190
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study is testing whether a less frequent dosing schedule of the drug enfortumab vedotin (EV), given alone or with pembrolizumab, can still control advanced bladder cancer. About 60 adults with locally advanced or metastatic urothelial carcinoma will receive EV on a modified schedule. The goal is to see if the reduced dosing maintains clinical benefit while potentially lowering side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
enfortumab vedotin (with or without pembrolizumab)
What this could lead to
If successful, this could show that a less frequent dosing schedule of enfortumab vedotin still controls advanced bladder cancer while reducing side effects.
What could go wrong
This is a small, early-phase pilot study with only 60 participants. The reduced schedule may not control the cancer as well as the standard schedule, and side effects remain possible.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Fox Chase Cancer Center - Philadelphia
Philadelphia, Pennsylvania, 19111-2497, United States