LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Clinical trials for LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM explained in plain language.
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Targeted pill trial offers hope for Tough-to-Treat cancers
Disease control Recruiting nowThis study is testing whether a pill called larotrectinib can help control advanced solid tumors that have a specific genetic feature (NTRK gene amplification). The trial is for patients aged 16 and older whose cancer has spread and who have already tried standard treatments. Res…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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Major trial uses genetic blueprint to find the right drug combo for advanced cancer
Disease control Recruiting nowThis trial is a large screening program that matches patients with advanced solid tumors to one of many smaller treatment studies. It uses genetic testing on a patient's tumor to find specific mutations. Patients are then assigned to a drug combination designed to target those mu…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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New trial tests if switching PARP inhibitors can help control advanced cancers
Disease control Recruiting nowThis study is testing whether the drug talazoparib can help control advanced cancers in patients whose tumors have specific mutations in genes that help repair DNA damage. It is enrolling 36 adults with various advanced solid tumors (like breast, ovarian, prostate, pancreatic, an…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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New cancer combo trial aims to boost immune attack on tumors
Disease control Recruiting nowThis study is testing whether adding an immunotherapy drug called durvalumab to standard chemotherapy is safe and can help the immune system better fight cancer. It is for adults with advanced solid tumors that have spread or cannot be removed by surgery. Researchers will monitor…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:28 UTC
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Scientists test 'Double Punch' drug combo for Tough-to-Treat stomach cancers
Disease control Recruiting nowThis early-stage study is testing the safety and best dose of a new two-drug combination for people with advanced cancers that have a specific marker called HER2. The trial focuses on stomach and gastroesophageal junction cancers that have spread or cannot be removed by surgery, …
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 24, 2026 12:02 UTC
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Targeted pill trial aims to control advanced cancers by blocking key growth signals
Disease control Recruiting nowThis study is testing an oral medication called avapritinib for people with advanced solid tumors that have spread and have specific genetic changes (mutations in the CKIT or PDGFRA genes). The drug aims to block the signals that help these tumor cells grow, potentially controlli…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 23, 2026 15:29 UTC
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Custom-Made vaccine aims to train immune system to fight advanced cancers
Disease control Recruiting nowThis study is testing a new, personalized vaccine designed to target the unique proteins on a patient's own cancer cells. It is being given alongside an existing immunotherapy drug (pembrolizumab) to see if the combination is safe and can help control advanced solid tumors that h…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1, PHASE2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Mar 20, 2026 14:48 UTC
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Scientists seek clues in blood to unlock cancer treatment mystery
Knowledge-focused Recruiting nowThis study aims to understand why some patients with advanced cancers like melanoma and lung cancer respond well to a common immunotherapy (anti-PD-1), while others do not. Researchers will collect blood samples from 500 patients to measure specific markers in immune cells during…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Mar 19, 2026 14:56 UTC