LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Clinical trials for LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM explained in plain language.
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Early trial tests drug combo to halt advanced cancer growth
Disease control OngoingThis early-stage study aims to find the safest and most effective dose of two oral medications, ceritinib and everolimus, when used together. It involves adults with advanced solid tumors or a specific type of lung cancer (ALK-positive non-small cell lung cancer) that has spread …
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Apr 01, 2026 18:41 UTC
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Targeted drug trial aims to halt growth of advanced tumors with genetic flaw
Disease control OngoingThis study is testing a drug called adavosertib in people with advanced solid tumors that have spread and have a specific genetic change called SETD2-deficiency. The goal is to see if the drug can shrink or stop the growth of these tumors by blocking enzymes the cancer cells need…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Apr 01, 2026 14:43 UTC
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Personalized immune cells tested to fight five tough cancers
Disease control TerminatedThis early-stage study aimed to test the safety and early effectiveness of a personalized cell therapy called STIL101. The therapy involved growing a patient's own cancer-fighting immune cells (T-cells) from a tumor sample in a lab and then infusing them back. It was designed for…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Mar 30, 2026 14:35 UTC
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Withdrawn cancer drug trial never started
Disease control TerminatedThis was an early safety study for an experimental cancer drug called CB-5339. It was designed to find the safest dose and check for side effects in adults with advanced solid tumors or lymphomas that had stopped responding to standard treatments. The study was withdrawn by the s…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 30, 2026 14:29 UTC
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New hope for tough cancers: trial tests drug duo to outsmart resistant tumors
Disease control TerminatedThis study is testing whether adding a targeted drug called ipatasertib to a standard chemotherapy (paclitaxel) can help control advanced solid tumors that have specific genetic changes and have stopped responding to similar chemotherapy drugs. It aims to see if this combination …
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 23, 2026 15:19 UTC
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Scientists test Triple-Threat attack on Tough-to-Treat cancers
Disease control OngoingThis study is testing a new three-part treatment for people with advanced cancers that have spread. It combines a new pill (peposertib), an immunotherapy drug (avelumab), and a short, high-dose course of radiation. The goal is to see if this combination can better control cancer …
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 23, 2026 15:18 UTC
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New combo therapy aims to fight the exhausting fatigue of advanced cancer
Symptom relief OngoingThis study is testing whether a combination of home-based exercise and a short course of a steroid medication (dexamethasone) can help reduce severe fatigue in people with advanced cancer. The trial involves 99 participants who will be randomly assigned to do exercise with either…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Apr 01, 2026 14:41 UTC
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Can they hear us? brain wave study seeks answers for families of dying patients
Knowledge-focused TerminatedThis study uses brain wave monitoring to understand if cancer patients who appear completely unresponsive near the end of life can still hear or understand words. Researchers will measure brain activity in response to speech and other stimuli in 30 patients. The goal is to provid…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:33 UTC