LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Clinical trials for LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM explained in plain language.
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New drug cocktail shows promise for Hard-to-Treat cancers
Disease control OngoingThis study tests a drug called ceralasertib, either alone or combined with olaparib or durvalumab, in people with advanced solid tumors like kidney, bladder, pancreatic, endometrial, and prostate cancers. The goal is to see if these combinations can shrink tumors or slow their gr…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: Rahul Aggarwal • Aim: Disease control
Last updated May 17, 2026 00:52 UTC
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Targeted drug shows promise for Gene-Deficient cancers
Disease control OngoingThis study tests a drug called adavosertib in 18 adults with advanced solid tumors that lack a working SETD2 gene. The drug works by blocking enzymes that cancer cells need to grow. The main goal is to see if the tumors shrink or stop growing.
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 17, 2026 00:45 UTC
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Triple threat against tough cancers: drug combo plus radiation shows promise
Disease control OngoingThis study tests a new combination of two drugs (peposertib and avelumab) plus a special type of radiation for people with advanced solid tumors or bile duct cancers that have spread. The goal is to find the safest dose and see if the treatment can shrink tumors. About 103 adults…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 15, 2026 11:56 UTC
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New combo targets Hard-to-Treat cancers with gene mutations
Disease control TerminatedThis study tests whether adding a targeted drug (ipatasertib) to standard chemotherapy (paclitaxel) can shrink or slow advanced solid tumors that have PTEN or AKT gene changes. About 33 adults whose cancer did not respond to taxane chemotherapy will receive the combination. The g…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 11, 2026 20:49 UTC
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New drug combo targets Hard-to-Treat cancers in early trial
Disease control OngoingThis early-phase study tests the safety and best dose of combining two drugs, ceritinib and everolimus, in people with advanced solid tumors or a specific type of lung cancer (ALK-positive NSCLC). The goal is to find the highest dose that is safe and to see if the combination can…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 11, 2026 20:39 UTC
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New immune cell therapy targets five Hard-to-Treat cancers
Disease control TerminatedThis early-stage trial was designed to test the safety of a new treatment called STIL101 for people with advanced pancreatic, colorectal, kidney, cervical cancer, or melanoma that has spread or cannot be removed. The treatment uses a patient's own immune cells (T cells) taken fro…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated May 05, 2026 11:53 UTC
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Cancer drug trial pulled before it even started
Disease control TerminatedThis was a Phase I trial testing a drug called CB-5339 in people with advanced solid tumors or lymphomas that had stopped responding to standard treatments. The goal was to find the best dose and check for side effects. However, the study was withdrawn before enrolling any partic…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 04, 2026 16:21 UTC
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New combo targets cancer fatigue: exercise plus steroid shows promise
Symptom relief OngoingThis study tests whether adding a steroid drug called dexamethasone to a physical activity program can better reduce severe fatigue in people with advanced cancer. About 99 participants will be assigned to exercise alone or exercise plus the drug. The goal is to see if the combin…
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated May 11, 2026 20:49 UTC
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Brain waves reveal if unresponsive patients hear loved ones in final days
Knowledge-focused TerminatedThis study uses a brain wave test (EEG) to check if cancer patients who appear unresponsive in their last days can still hear or feel. Researchers will measure brain activity before and after speaking to them. The goal is to help families and doctors understand what patients may …
Matched conditions: LOCALLY ADVANCED MALIGNANT SOLID NEOPLASM
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated May 15, 2026 11:57 UTC