ISCHEMIC CARDIOMYOPATHY

This study tests whether stem cells from umbilical cords can safely improve heart function in people with heart failure due to blocked arteries. Sixty participants will receive either one or two doses of stem cells or a placebo through an IV. The main goal is to see if the heart'…

This study compares two approaches for people with ischemic cardiomyopathy (weak heart muscle due to blocked arteries) and multiple blocked vessels. One group gets optimal medical therapy alone, while the other also gets a heart artery procedure (PCI) guided by imaging and pressu…

This study tests whether adding a vein-injected alcohol treatment to the usual heart ablation procedure can better control dangerous heart rhythms in people with prior heart attacks. About 156 adults with an implanted defibrillator and recent episodes of rapid heartbeat will be r…

This study tests if a single low-dose radiation treatment to the whole heart can improve heart function in people with advanced heart failure. About 40 adults with severe heart failure who are not eligible for a heart transplant will receive this treatment. The goal is to see if …

This study tests whether using an AI tool (Ablation Index) during heart ablation can shorten the procedure for patients with ventricular tachycardia caused by prior heart attacks. About 100 adults with ischemic cardiomyopathy and scar-related VT will be randomly assigned to stand…

This study tests whether a newer pacing method called left bundle branch pacing (LBBP) works better than the standard biventricular pacing for people with chronic heart failure and reduced pumping ability. About 60 adults with heart failure and a specific electrical delay in the …

This phase 2 study tests a new radioactive imaging agent, 18F-mFBG, to measure nerve damage in the hearts of 20 people with stable heart failure and implantable defibrillators (ICDs). The goal is to see if the agent can reveal differences in nerve function between those who have …

This study tests a new PET imaging method that uses a special tracer called XTR003 along with FDG to see which parts of the heart are still alive in people with heart failure from blocked arteries. About 40 to 60 participants will be randomly assigned to receive either the new fa…

This study uses a special catheter to record detailed electrical signals from the heart during a standard procedure for dangerous heart rhythms (ventricular tachycardia). Researchers aim to better understand why these rhythms start and how to pinpoint the exact trouble spots. Ten…

This study follows 30,000 adults with coronary artery disease to see how different risk factors affect their long-term survival. Researchers will track deaths from any cause and from heart problems specifically. The goal is to better understand what influences outcomes in real-wo…

This study is testing a new type of MRI scan that looks at how the heart uses energy. It involves 15 people: 6 healthy volunteers and 9 patients with severe heart disease who are scheduled for bypass surgery. The goal is to see if this new scan can better measure heart muscle hea…

This study is looking at 400 people with weak hearts who are getting an implantable defibrillator (ICD) to prevent sudden cardiac death. Researchers want to see if detailed heart MRI scans can find structural problems that better predict who will actually have a dangerous heart r…

This study is for adults with a weak heart muscle and a leaky mitral valve (functional mitral regurgitation). Researchers will use advanced MRI scans to better predict which treatments—medication or a minimally invasive valve repair—will work best for each person. The goal is to …