INTERSTITIAL LUNG DISEASE (ILD)

This study tests whether JAK inhibitors work better than calcineurin inhibitors as the first treatment for lung scarring in people with antisynthetase syndrome. About 80 adults with active lung disease will be followed for 12 months to see which drug improves breathing and surviv…

This study tests a new inhaled drug, mosliciguat, added to an existing treatment (treprostinil) for people with high blood pressure in the lungs caused by lung scarring. The goal is to see if the combination is safe and tolerable. About 20 adults with this condition will particip…

This early-stage trial tests a single dose of an inhaled drug called RJ026 in 42 healthy volunteers and 42 people with interstitial lung disease (ILD). The goal is to see how much drug reaches the lungs and blood, and whether it is safe. Researchers hope that inhaling the drug wi…

This study tests whether tetrandrine tablets can improve lung function in people with interstitial lung disease caused by connective tissue disease (like lupus or scleroderma). One hundred adults will receive either tetrandrine or a placebo for 24 weeks, alongside their usual tre…

This study compares two ways of using a heart-lung support machine (ECMO) during lung transplants: using it routinely for all patients versus using it only when problems arise. About 218 adults with end-stage lung disease will take part. The goal is to see which approach leads to…

This study aims to find better, non-invasive tests to diagnose and predict the course of interstitial lung disease (ILD). Researchers will test blood and breath samples from 750 people, including pigeon fanciers at high risk for ILD and patients already diagnosed. The goal is to …

This study tests whether an artificial intelligence (AI) tool that analyzes a simple ECG can help doctors find undiagnosed pulmonary hypertension (high blood pressure in the lungs) in people with interstitial lung disease. About 900 adults with severe lung scarring will be random…

This study tests whether using a robotic arm during a lung biopsy helps doctors get better tissue samples to diagnose interstitial lung disease. About 30 adults with unclear CT scans will be randomly assigned to either standard or robotic-assisted bronchoscopy. The goal is to see…

This study tests whether three 15-minute hypnosis sessions can help people with persistent breathlessness from cancer, COPD, interstitial lung disease, or chronic heart failure feel more in control of their breathing. Researchers will measure changes using a standard questionnair…

This study tests whether L-menthol, a minty compound, can reduce breathlessness and help people with interstitial lung disease (ILD) exercise longer. About 20 adults with ILD will try L-menthol and a placebo in random order, comparing their breathing and exercise ability. The goa…

This study aims to see if bundling all routine tests and doctor visits into one coordinated hospital trip can save time for people with interstitial lung disease. About 152 adults with the condition will either receive standard care or the new streamlined approach. The goal is to…

This study aims to understand why breathlessness varies among people with different lung diseases like COPD, asthma, and ILD. Researchers will measure lung function, exercise ability, and breathing patterns in 75 participants (50 with lung disease and 25 healthy controls). The go…

This study is testing whether people with pulmonary fibrosis can safely replace half of their regular clinic visits with home monitoring. Participants will use a home spirometer, pulse oximeter, and a smartphone app to track their health and communicate with their care team. The …

This study tests whether bundling key tests like scans and lung function tests into a single, fast-tracked appointment can help people with suspected interstitial lung disease get a diagnosis sooner. About 92 adults will be randomly assigned to either the usual step-by-step testi…