IMMUNODEFICIENCY
Clinical trials for IMMUNODEFICIENCY explained in plain language.
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Could a stem cell transplant tame VEXAS? new trial aims to find out
Disease control Recruiting nowThis study tests whether a stem cell transplant from a healthy donor can control VEXAS syndrome, a rare and serious inflammatory disease. About 54 adults aged 18 to 75 whose standard treatments have failed will receive donor stem cells after chemotherapy and possibly radiation. T…
Matched conditions: IMMUNODEFICIENCY
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 17, 2026 02:58 UTC
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New hope for vulnerable patients: study tests stronger COVID-19 antiviral cocktails
Disease control Recruiting nowThis study looks at whether combining two antiviral drugs (remdesivir and nirmatrelvir/r) works better than one drug alone for treating COVID-19 in people with weakened immune systems. It also tests if taking the medication for 10 days instead of 5 helps clear the virus faster. A…
Matched conditions: IMMUNODEFICIENCY
Phase: PHASE2 • Sponsor: Calmy Alexandra • Aim: Disease control
Last updated Jun 15, 2026 19:06 UTC
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New cell addback may shield kids from deadly infections after transplant
Disease control Recruiting nowThis study tests whether adding a special type of immune cell (memory T cells) after a stem cell transplant can help children fight off viral and fungal infections. About 100 children and young adults with blood cancers, immune disorders, or bone marrow failure will receive this …
Matched conditions: IMMUNODEFICIENCY
Phase: PHASE1, PHASE2 • Sponsor: Children's Hospital of Philadelphia • Aim: Disease control
Last updated Jun 15, 2026 19:04 UTC
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New hope for vulnerable patients: shorter, stronger COVID-19 treatment on trial
Disease control Recruiting nowThis study tests whether combining two antiviral drugs or taking them for longer helps people with weakened immune systems clear COVID-19 faster. About 256 participants with mild or no symptoms will receive either standard treatment or a combination therapy. The goal is to find a…
Matched conditions: IMMUNODEFICIENCY
Phase: PHASE2 • Sponsor: ANRS, Emerging Infectious Diseases • Aim: Disease control
Last updated Jun 11, 2026 12:10 UTC
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New stem cell trial offers hope for rare immune disorder
Disease control Recruiting nowThis study tests whether a stem cell transplant from a healthy donor can treat GATA2 deficiency, a rare genetic condition that weakens the immune system and raises the risk of leukemia. Participants aged 6 to 70 receive chemotherapy or radiation before the transplant to prepare t…
Matched conditions: IMMUNODEFICIENCY
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 08, 2026 13:04 UTC
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Parkinson's drug may weaken immunity: new study investigates
Knowledge-focused Recruiting nowThis study looks at whether clozapine, a drug used to treat psychosis in Parkinson's disease, weakens the immune system over time. Researchers will measure immune markers in 24 patients before and after 6 and 12 months of treatment. The goal is to understand infection risks in th…
Matched conditions: IMMUNODEFICIENCY
Phase: PHASE4 • Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Knowledge-focused
Last updated Jun 15, 2026 19:07 UTC
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Massive gene hunt aims to unlock secrets of immune disorders
Knowledge-focused Recruiting nowThis study is looking for the genes that cause certain immune system problems. It will enroll up to 5,000 people with these disorders and their family members. By analyzing blood and other samples, researchers hope to better understand these conditions and improve diagnosis and g…
Matched conditions: IMMUNODEFICIENCY
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Jun 15, 2026 19:04 UTC
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New study to reveal hidden immune defenses in vulnerable patients
Knowledge-focused Recruiting nowThis study looks at how well vaccines against respiratory viruses (like flu and COVID-19) work in people with weakened immune systems. Researchers will track 1,000 adults who are either immunocompromised due to illness or treatment. The goal is to measure both antibody and T-cell…
Matched conditions: IMMUNODEFICIENCY
Sponsor: University of Cologne • Aim: Knowledge-focused
Last updated May 22, 2026 14:02 UTC