IBS (IRRITABLE BOWEL SYNDROME)

This study tests whether a daily enzyme supplement (FODZYME®) can reduce bloating and stomach pain in adults who often feel bloated. About 150 people will take either the enzyme or a placebo for a period, then switch, to see if the enzyme helps break down hard-to-digest carbs. Th…

This study tests a non-invasive belt-like device (Variable Compression System) for people with moderate to severe Irritable Bowel Syndrome (IBS). Twenty participants will wear the device for at least 6 hours daily to see if it safely reduces IBS symptoms like pain, bloating, and …

This study tests whether adding the supplement N-acetylcysteine (NAC) to the antibiotic rifaximin can better relieve symptoms of irritable bowel syndrome with diarrhea (IBS-D). The idea is that NAC may break down mucus in the gut, helping rifaximin work more effectively. The tria…

This study tests whether ebastine, an allergy medication, works better than mebeverine, a common IBS drug, for reducing belly pain and improving daily life. About 200 adults with non-constipated IBS will take one of the two pills for 12 weeks. The goal is to see if ebastine provi…

This study tests whether a daily drink mix containing special sugars (HMO-2FL) and a postbiotic can reduce stomach pain, bloating, and other IBS symptoms. About 402 adults with IBS will take either the supplement or a placebo for 6 weeks. Researchers will compare symptom scores t…

This early-phase study at Mayo Clinic tests whether adding the medication mirtazapine to a low-FODMAP diet improves symptoms of irritable bowel syndrome with diarrhea (IBS-D) better than diet alone. About 20 adults aged 18-70 will take either mirtazapine or a placebo while follow…

This study tests whether low-frequency magnetic stimulation to a brain area linked to pain can reduce chronic visceral pain in people with irritable bowel syndrome with diarrhea (IBS-D). 42 adults will receive either real or sham stimulation daily for two weeks. The goal is to se…

This study tests whether a probiotic called Saccharomyces boulardii can reduce symptoms of irritable bowel syndrome (IBS) in adults. About 406 people with non-constipated IBS will take either the probiotic or a placebo daily for 8 weeks. Researchers will measure changes in sympto…

This study aims to find out how many relatives of people with celiac disease have non-celiac wheat sensitivity (NCWS) or other gut issues like IBS. Participants will follow a strict wheat-free diet for 6 weeks and report their symptoms. The goal is to better understand the link b…

This study looks at people with Irritable Bowel Syndrome (IBS) who have a reduced ability to break down starch and sugar due to low enzyme levels. Researchers want to see if these individuals have a smaller rise in blood sugar after a meal and more bowel symptoms compared to thos…

This observational study is looking at the gut microbiome of 315 people, including those with irritable bowel syndrome that started after an infection. Researchers will compare their gut bacteria to people who had an infection but no IBS, and to healthy controls. The goal is to f…