Could a Mucus-Busting supplement boost an IBS drug?
NCT ID NCT06727422
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding the supplement N-acetylcysteine (NAC) to the antibiotic rifaximin can better relieve symptoms of irritable bowel syndrome with diarrhea (IBS-D). The idea is that NAC may break down mucus in the gut, helping rifaximin work more effectively. The trial will enroll 225 adults with IBS-D who still have symptoms despite standard care. Participants will receive one of two doses of the combination or a placebo for several weeks, and researchers will track changes in abdominal pain and stool consistency.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
rifaximin and N-acetylcysteine (NAC) combination
What this could lead to
If it works, this could offer a more effective treatment for IBS-D symptoms, reducing abdominal pain and diarrhea better than current options.
What could go wrong
This is an early phase 2b trial with only 225 participants. The combination is not yet approved, and it may not prove more effective than rifaximin alone. Side effects are possible.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cedars-Sinai Medical Center
RECRUITINGLos Angeles, California, 90048, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••