HPV-RELATED CARCINOMA

This Phase 3 trial is testing an 11-valent HPV vaccine in 13,500 Chinese women aged 18-45. The vaccine targets 11 types of HPV linked to cervical cancer and genital warts. Participants receive three shots over six months and are monitored for several years to see if the vaccine p…

This study tests a new 15-valent HPV vaccine to see if it is safe and triggers a strong immune response. It involves 330 healthy Chinese volunteers aged 9 to 45. Participants will receive three doses of the vaccine or a placebo, and researchers will monitor side effects and measu…

This study tests whether a blood test (ctDNA) can help doctors customize the dose of chemoradiation for people with anal cancer. Depending on how the tumor responds, some patients may get a lower radiation dose to reduce side effects, while others may get a higher dose or an adde…

This study tests whether a single infusion of a patient's own genetically engineered immune cells (E7 TCR-T cells) can shrink or eliminate HPV-related cancers before the patient receives standard treatment like chemo-radiation or surgery. The trial enrolls 15 adults with advanced…

This study tests a new immunotherapy for people with advanced HPV-related cancers, such as cervical, throat, anal, and penile cancers. Participants receive specially engineered immune cells designed to attack cancer cells carrying the HPV16 virus. The goal is to see if this treat…

This phase 2 study is testing whether adding an experimental therapy called PRGN-2009 to the immunotherapy drug pembrolizumab can help shrink tumors in people with recurrent or metastatic cervical cancer that has stopped responding to pembrolizumab alone. About 24 adults with HPV…

This study is testing whether a blood test that detects HPV DNA can help doctors decide who needs radiation after surgery for HPV-related oropharynx cancer. In one group, patients with no detectable HPV DNA after surgery will be watched closely and only get radiation if the test …

This study is testing a simple blood test that looks for tumor DNA from HPV-related cervical and anal cancers after radiation treatment. The goal is to see if this test can replace expensive imaging scans and help doctors find early signs of cancer returning. If the test is posit…

This study is testing whether a simple mouth rinse can detect HPV-related throat cancer early, before symptoms appear. Researchers will compare results from 200 people with throat cancer and 200 healthy volunteers matched by age, sex, and background. If accurate, this test could …

This study looks at whether a blood test can detect HPV DNA in people with HPV-related anal or cervical cancer who are receiving radiation therapy. Researchers will collect blood samples before, during, and after treatment to see if the virus's genetic material shows up and if it…