HPV-RELATED CARCINOMA

This study tests an experimental vaccine that targets 11 types of HPV, the virus that causes cervical cancer. About 13,500 Chinese women aged 18-45 will receive either the vaccine or a placebo over 6 months. The goal is to see if the vaccine prevents serious cervical cell changes…

This study tests a new 15-valent HPV vaccine to see if it is safe and triggers a strong immune response. It involves 330 healthy Chinese volunteers aged 9 to 45. Participants receive three doses of the vaccine or a placebo, and researchers monitor side effects and antibody levels…

This study tests a new immunotherapy for people with advanced HPV-related cancers (cervical, throat, anal, and others). Participants receive specially engineered immune cells designed to attack HPV-infected tumor cells, along with chemotherapy and a drug to boost cell activity. T…

This study tests a new drug, PRGN-2009, combined with pembrolizumab in 24 adults whose recurrent or metastatic cervical cancer no longer responds to pembrolizumab alone. The goal is to see if the combination can shrink tumors or stop them from growing. Participants must have HPV-…

This study tests whether giving a single dose of specially engineered immune cells (E7 TCR-T cells) before standard treatment (chemoradiation or surgery) can shrink or eliminate tumors in people with advanced HPV-related cancers. About 15 participants will have their own T cells …

This study is testing a new, low-cost blood test that looks for tumor DNA (ctDNA) in people with HPV-related cervical or anal cancer after they finish radiation therapy. The goal is to see if this simple blood test can replace expensive imaging scans for monitoring and help docto…

This study is for people with HPV-related throat cancer who have had or will have surgery. Researchers will use a blood test that looks for cancer DNA (HPV ctDNA) to decide if radiation therapy is needed. In one group, patients with no detectable cancer DNA after surgery will ski…

This study is testing a new mouth swab test that looks for HPV DNA and certain gene changes to find throat cancer early. Researchers will compare results from 200 people with throat cancer and 200 healthy volunteers matched by age, sex, and background. If the test works well, it …

This study looks at whether a simple blood test can find HPV DNA in people with HPV-related anal or cervical cancer who are getting radiation therapy. Researchers will take blood samples before, during, and after treatment to see if the virus's genetic material shows up and if it…