HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS
Clinical trials for HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS explained in plain language.
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Suicide Gene-Equipped t cells aim to make stem cell transplants safer
Disease control OngoingThis trial tests whether specially modified T cells from a partially matched donor can help patients recover their immune system faster after a stem cell transplant. The T cells are engineered with a 'suicide gene' that allows doctors to destroy them if they cause graft-versus-ho…
Matched conditions: HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS
Phase: PHASE1 • Sponsor: Baylor College of Medicine • Aim: Disease control
Last updated Jul 02, 2026 05:00 UTC
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Engineered t cells with a kill switch aim to make stem cell transplants safer
Disease control OngoingThis study tests a new approach for people receiving a stem cell transplant from a partially matched family donor. The donor's immune cells (T cells) are modified in the lab to include a 'suicide gene' that can be activated by a drug if the cells attack the patient's body, causin…
Matched conditions: HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS
Phase: PHASE1 • Sponsor: Baylor College of Medicine • Aim: Disease control
Last updated Jul 02, 2026 05:00 UTC
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Stem cell transplant offers new hope for kids with rare immune diseases
Disease control OngoingThis study tests a donor stem cell transplant for people with severe immune system problems, like SCID and Wiskott-Aldrich syndrome. The goal is to help the body make healthy blood cells and fight infections. Participants receive donated stem cells to rebuild their immune system.…
Matched conditions: HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS
Phase: NA • Sponsor: Masonic Cancer Center, University of Minnesota • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Gentler transplant shows promise for kids with blood diseases
Disease control OngoingThis study tests a milder chemotherapy and immune-suppressing regimen before a stem cell transplant for children and young adults with non-malignant blood disorders like sickle cell disease or immune deficiencies. The goal is to safely achieve donor cell engraftment with fewer si…
Matched conditions: HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS
Phase: PHASE2 • Sponsor: Children's Hospital of Philadelphia • Aim: Disease control
Last updated Jun 27, 2026 12:28 UTC
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New drug cocktail aims to tame deadly immune storm in kids
Disease control OngoingThis study tests a combination of three drugs—ruxolitinib, dexamethasone, and etoposide—for children and young adults with hemophagocytic lymphohistiocytosis (HLH), a rare condition where the immune system attacks the body. The trial includes two groups: newly diagnosed patients …
Matched conditions: HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS
Phase: PHASE1, PHASE2 • Sponsor: St. Jude Children's Research Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Milder stem cell transplant shows promise for kids with immune disorders
Disease control OngoingThis study tests a stem cell transplant using a milder chemotherapy-like regimen to treat children and young adults (up to age 28) with various immune system disorders. The goal is to help the donor stem cells settle in the body with fewer side effects. The study involves 20 part…
Matched conditions: HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS
Phase: PHASE2 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 09:06 UTC
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New stem cell approach could fix immune systems in kids
Disease control OngoingThis Phase II trial tests a stem cell transplant from unrelated or partially matched family donors for children and young adults with severe immune deficiencies. The stem cells are specially processed to remove certain immune cells, aiming to reduce complications. The goal is to …
Matched conditions: HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS
Phase: PHASE2 • Sponsor: Children's Hospital of Philadelphia • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC