HAEMATOLOGICAL MALIGNANCY

This trial tests two drugs, trastuzumab and pertuzumab, already approved for breast cancer, in people with rare cancers that have a specific genetic change called HER2 amplification or mutation. About 30 adults and children with various rare cancers will receive the drug combinat…

This study tests capmatinib, a drug already approved for certain lung cancers, in adults with rare cancers that have specific MET gene changes. About 30 people will take part to see if the drug can shrink tumors or stop cancer from growing for at least 24 weeks. The goal is to fi…

This study tests whether using a person's genetic information to decide the dose of voriconazole (an antifungal medicine) helps more patients reach the right drug level in their blood compared to standard dosing. The trial will include about 104 children and adults with blood can…

This study tests a new drug called CCS1477 in people with advanced blood cancers like leukemia, lymphoma, and multiple myeloma. The goal is to see if the drug is safe and can help control the disease. About 250 participants will receive the drug alone or with other treatments.

This study tests a drug called entrectinib in people with rare cancers that have a specific gene change (ROS1 fusion). The drug is already approved for some lung cancers, and researchers want to see if it helps shrink tumors or stop them from growing in other cancer types. About …

This study tests two drugs, vemurafenib and cobimetinib, already approved for melanoma, in adults with rare cancers that have a specific BRAF V600 mutation. About 30 people with various cancer types will receive the combination to see if it shrinks tumors or prevents growth for a…

This study tests a drug called alectinib, already approved for some lung cancers, in people with rare cancers that have a specific genetic change called ALK. About 30 adults, teens, and children with ALK-positive cancers will receive alectinib to see if it shrinks tumors or stops…

This study tests whether drugs already approved for some cancers can help people with rare cancers or common cancers that have rare genetic changes. It includes adults, teenagers, and children whose cancer has a specific mutation and who have no good standard treatment left. The …