GLIOSARCOMA

This study tests a vaccine called SurVaxM, given with standard chemotherapy, for people with a newly diagnosed aggressive brain cancer (glioblastoma). The vaccine is designed to train the immune system to attack cancer cells. The main goal is to see if adding the vaccine helps ke…

This early-phase study tests whether adding the experimental drug S-Gboxin to standard radiation and chemotherapy can help people with glioblastoma or diffuse midline glioma, two aggressive brain cancers. About 10 participants whose tumors have returned or worsened will receive t…

This study tests whether adding the drug veliparib to standard chemotherapy (temozolomide) helps people with a newly diagnosed, aggressive brain cancer called glioblastoma live longer. The trial includes 447 adults whose tumors have a specific genetic marker (MGMT hypermethylatio…

This early-phase trial tests a new drug called selinexor alongside standard chemotherapy and radiation for people with newly diagnosed glioblastoma, a fast-growing brain cancer. The main goal is to find the highest safe dose of selinexor that can be given with the standard treatm…

This study tests whether adding a second chemotherapy drug, lomustine, to the standard treatment (temozolomide plus radiation) helps people with a specific type of glioblastoma (a fast-growing brain cancer). The trial includes 265 newly diagnosed patients whose tumors have a gene…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy and radiation can help people with newly diagnosed glioblastoma, a fast-growing brain cancer. About 52 adults will receive the combination therapy to see if it improves survival and cont…

This trial tests a device implanted in the skull that uses ultrasound to temporarily open the blood-brain barrier, allowing chemotherapy drugs to reach brain tumors more effectively. About 57 adults with recurrent glioblastoma will receive this treatment after surgery to remove t…

This study looks at whether a special type of MRI (DSC-MRI) can measure blood flow changes in brain tumors to quickly tell if a drug called bevacizumab is working. About 146 adults with recurrent glioblastoma will get the MRI before and after starting treatment. The goal is to se…