GLIOMA, MALIGNANT

This early-phase trial tests a vaccine made from small protein pieces (peptides) designed to train the immune system to attack glioblastoma, a fast-growing brain cancer. The study includes 24 adults with newly diagnosed, untreated glioblastoma that has a specific genetic marker. …

This early-phase study tests whether giving multiple doses of a special virus carried by neural stem cells is safe and possible for people with newly diagnosed high-grade glioma. Participants receive the therapy directly into the brain before, during, and after standard radiation…

This early-stage trial tests a new surgical approach for recurrent glioblastoma, an aggressive brain cancer. After standard tumor removal, surgeons place a piece of abdominal tissue (omentum) into the brain cavity to bypass the blood-brain barrier. The study involves 10 adults an…

This early-phase trial tests whether adding the drug AZD1390 to standard radiation therapy can help people with a fast-growing brain tumor called glioblastoma (grade 4 glioma). The study includes both newly diagnosed and recurrent patients. First, researchers measure how much dru…

This early-phase trial tests the drug niraparib (Zejula) in people with two types of brain cancer: newly diagnosed glioblastoma and recurrent glioma with specific genetic changes (IDH mutation and ATRX loss). The study first checks if the drug reaches the tumor tissue, then gives…

This study looks at whether simple blood tests can help doctors understand how glioblastoma, a serious brain cancer, changes over time. About 100 newly diagnosed patients will give blood samples before and after standard radiation and chemotherapy. The goal is to see if DNA from …

This early-stage trial enrolls 16 adults with recurrent IDH-mutant gliomas who are scheduled for surgery. Participants take niraparib for one month before their operation so researchers can measure how much drug reaches the tumor and how it affects cancer cells. The goal is to ga…

This study looks at how aggressive brain tumors (gliomas) suppress the immune system. Researchers will use special MRI and PET scans to track immune cells and iron levels in the tumor. The goal is to find better ways to measure immune suppression, which could help develop new tre…