Gastroesophageal reflux disease

Researchers compare two versions of sleeve gastrectomy in adults with obesity: one with an added step called omentopexy, where the stomach sleeve is attached to nearby fatty tissue, and one without. The main question is whether adding omentopexy lowers the number of people who de…

This phase 2 trial tests whether a combination of fosamprenavir (an HIV medication) and sodium alginate (a seaweed-based thickener) can ease heartburn and regurgitation in people whose reflux doesn't improve with standard acid-blocking pills. Sixty adults aged 18 to 65 will take …

Researchers compare diaphragm mechanics, breathing muscle strength, and chest-abdomen movement in three groups of women aged 60 and older with obesity: those with GERD and a past abdominoplasty, those with abdominoplasty alone, and those with GERD alone. Participants undergo ultr…

Researchers are testing whether a 14-day course of omeprazole, a common acid reflux drug, changes the mix of bacteria in the gut and mouth. The trial enrolls 26 adults aged 50 to 65 who have obesity and mild to moderate gastroesophageal reflux symptoms. Half receive omeprazole pl…

This study will collect data from 10,000 people undergoing upper endoscopy to build an AI model that predicts the risk of developing stomach or esophageal cancer. Researchers will combine information from endoscopy images, tissue samples, genetics, and gut bacteria. Participants …

This study compares how two weight-loss surgeries—gastric bypass and sleeve gastrectomy—affect acid reflux in 128 obese patients. Participants will be randomly assigned to one surgery, and their reflux will be measured before and after using a 24-hour pH test. The goal is to see …

This study will examine how metabolic syndrome—a cluster of conditions like high blood pressure, high blood sugar, and excess belly fat—relates to gastroesophageal reflux disease (GERD). Researchers will enroll 50 adults with metabolic syndrome and use an endoscopy to check for s…