Gastroesophageal reflux disease

This registry follows thousands of adults who undergo laparoscopic surgery for gastroesophageal reflux disease (GERD) or hiatal hernia. It compares two common procedures: fundoplication, which wraps part of the stomach around the esophagus to reinforce the valve, and the LINX dev…

This study looked at whether a specific keyhole surgery (Toupet fundoplication) can help people with a hiatal hernia that causes heartburn but doesn't show up on X-rays. 100 adults with this condition had the surgery and were followed to see if their symptoms came back or if they…

This study tested whether adding a crural repair and gastropexy to standard sleeve gastrectomy reduces acid reflux in people with severe obesity. Fifty patients were randomly assigned to either the standard surgery or the enhanced version. After one year, the group with the extra…

This study tested whether adding a gut-brain neuromodulator (Flupentixol-Melitracen) to standard acid-reducing therapy (Lansoprazole) helps people with gastroesophageal reflux disease (GERD) who still have symptoms on acid suppressants alone. The trial enrolled 164 adults with GE…

Researchers compare two versions of laparoscopic sleeve gastrectomy in adults with obesity and reflux symptoms. One group receives standard surgery, and the other receives surgery plus posterior gastropexy, a step that stitches the stomach to the back wall to discourage reflux. T…

Many people with gastroesophageal reflux disease still have heartburn even when they take proton pump inhibitors. The SIRUP trial compares the Stretta procedure, which uses radiofrequency energy on the esophagus, with a sham procedure in adults who have at least three heartburn e…

This completed study looked at whether FEXUCLUE (fexuprazan) tablets can improve heartburn and acid reflux symptoms in people with erosive gastroesophageal reflux disease (GERD). Over 2,800 adults took the medication for 4 to 8 weeks and reported their symptom changes. The goal w…

This study is not testing a new treatment. Instead, it follows 500 people who already had a procedure called TIF (transoral incisionless fundoplication) for acid reflux. Researchers will collect data from medical records to see how symptoms and quality of life change over time. T…

Researchers at Massachusetts General Hospital are studying whether certain DNA variations and health factors raise the risk of Barrett's esophagus, a condition that can precede esophageal cancer. The study enrolls about 170 people who are having an upper endoscopy to check Barret…

This early study looked at how two approved constipation drugs, plecanatide and linaclotide, affect a chemical called cGMP in the small intestine. Researchers compared tissue samples from 43 adults with Barrett esophagus or GERD who took either drug or no drug. The goal was to me…

This study looked at how many people in Xiamen have gastroesophageal reflux disease (GERD) and what factors might increase their risk. Researchers surveyed 1625 adults who had typical reflux symptoms like heartburn. The goal was to better understand the disease's impact and help …

This completed study surveyed over 700 primary care doctors, gastroenterologists, and patients across seven U.S. health systems. The goal was to find out what knowledge gaps, attitudes, and practical barriers prevent people from getting screened for Barrett's esophagus, a conditi…