FRAGILE X SYNDROME
Clinical trials for FRAGILE X SYNDROME explained in plain language.
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New drug shows promise for fragile x symptoms in small trial
Symptom relief CompletedThis study tested a single dose of SPG601 in 10 adult men with Fragile X syndrome to see if it improves symptoms like attention and behavior. Participants were randomly assigned to receive either the drug or a placebo, and neither they nor their doctors knew which they got. The g…
Matched conditions: FRAGILE X SYNDROME
Phase: PHASE2 • Sponsor: Spinogenix • Aim: Symptom relief
Last updated Jun 27, 2026 12:37 UTC
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Experimental drug aims to boost thinking skills in teens with fragile x
Symptom relief CompletedThis study tested a drug called zatolmilast (BPN14770) in 163 male adolescents aged 9 to 18 with Fragile X syndrome. The trial had two parts: one to check how the drug moves through the body, and another where some teens got the drug and others got a placebo. Researchers measured…
Matched conditions: FRAGILE X SYNDROME
Phase: PHASE2, PHASE3 • Sponsor: Tetra Discovery Partners • Aim: Symptom relief
Last updated Jun 27, 2026 09:01 UTC
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Diabetes drug metformin tested for fragile x symptoms
Symptom relief CompletedThis study tested whether metformin, a common diabetes medication, can help improve language, behavior, and weight problems in people with fragile X syndrome. 125 participants aged 6 to 35 took either metformin or a placebo for 4 months. Researchers measured changes in language s…
Matched conditions: FRAGILE X SYNDROME
Phase: PHASE2 • Sponsor: University of Alberta • Aim: Symptom relief
Last updated Jun 27, 2026 08:09 UTC
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CBD gel shows promise for fragile x behaviors in major trial
Symptom relief CompletedThis study tested a cannabidiol (CBD) gel, called ZYN002, applied to the skin in 215 children, teens, and young adults with Fragile X syndrome. The goal was to see if it could improve behavioral symptoms like irritability and social withdrawal. Participants received either the CB…
Matched conditions: FRAGILE X SYNDROME
Phase: PHASE3 • Sponsor: Zynerba Pharmaceuticals, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 08:04 UTC
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Brain-Body signals could reveal hidden patterns in autism, ADHD, and Alzheimer's
Knowledge-focused CompletedThis completed study at Rutgers University looked at how the brain and body communicate in 30 people with conditions like autism, ADHD, Alzheimer's, and Parkinson's. Participants performed natural movements like walking and pointing while their brain, heart, and motion signals we…
Matched conditions: FRAGILE X SYNDROME
Sponsor: Rutgers University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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Brain wave study tests new drug for fragile x syndrome
Knowledge-focused CompletedThis study looked at how a single dose of gaboxadol affects brain activity in adult males with Fragile X syndrome. Ten participants aged 18 to 40 took either the drug or a placebo during home and clinic visits. The main goal was to measure changes in brain waves using EEG, not to…
Matched conditions: FRAGILE X SYNDROME
Phase: PHASE2 • Sponsor: Craig Erickson • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC
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NIH study aims to sharpen research skills by evaluating kids with genetic disorders
Knowledge-focused CompletedThis completed study at the NIH enrolled 96 children with known or suspected genetic disorders, including autism and Fragile X syndrome. The main goal was to give clinic staff hands-on experience and explore new research ideas. Participants received medical exams, lab tests, and …
Matched conditions: FRAGILE X SYNDROME
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC