DENGUE

This study tested whether a new dengue vaccine candidate (V181) was as safe and effective at triggering an immune response as an existing dengue vaccine (Butantan-DV). It involved 1,364 healthy adults in Brazil aged 18-50 who had never had dengue before. Researchers compared the …

This small, early study tested whether giving an existing dengue vaccine as a shallow skin shot, instead of the usual deeper injection, could still build strong immunity. Researchers wanted to see if this method could make vaccination cheaper and potentially cause fewer side effe…

This study tested whether an oral medication called fenretinide (ISLA101) could control dengue virus infection. Fifteen healthy volunteers were given either the drug or a placebo, then deliberately exposed to a weakened form of the dengue virus. Researchers measured if the drug, …

This study tested whether spraying a special insecticide inside homes could prevent children from getting sick from diseases spread by Aedes mosquitoes, like dengue, Zika, and chikungunya. Researchers in Mexico enrolled over 4,400 children, aged 2 to 15, living in selected neighb…

This study aimed to understand how the human immune system responds to mosquito bites. Healthy volunteers were exposed to controlled bites from specific mosquito species that can carry malaria or dengue. Researchers measured antibody levels in the volunteers' blood over time to i…

This small study aimed to find out if the dengue virus can be present in semen during an active infection. Researchers tested 10-15 men with confirmed dengue to see if the virus was in their sperm and if standard sperm washing techniques could remove it. The goal was to better un…