CUSHING SYNDROME

This early-stage study tests an experimental pill called CRN04894 in 18 adults with Cushing's syndrome caused by too much ACTH hormone. The drug works by blocking the receptor that ACTH acts on, aiming to lower cortisol levels and control the disease. The main goals are to check …

This study tests a drug called osilodrostat in children aged 2 to 17 with Cushing's syndrome, a condition where the body makes too much cortisol. The goal is to see how the drug is processed, how well it works, and if it is safe. Only 12 children will take part, and they must wei…

This study aims to improve how doctors diagnose Cushing's syndrome, a condition caused by too much cortisol. Researchers will test the accuracy of the desmopressin stimulation test in 140 people aged 18-70 who have or may have Cushing's, plus healthy volunteers. Participants will…

This observational study will measure salivary cortisol in 220 healthy adults and people with Cushing's syndrome or adrenal insufficiency. The goal is to establish normal reference ranges and find the best cut-off values for diagnosis. Researchers will compare two lab methods to …

This study looks at how people recover from Cushing syndrome after surgery. Researchers want to understand what affects recovery and whether using a MUSE biofeedback headband can help ease withdrawal symptoms. The study will include 700 adults who are planning to have curative su…

This study aims to learn more about how adrenal tumors form and to test new treatment options for adrenal cancer. Researchers will study up to 500 adults who have an adrenal tumor seen on imaging. The goal is to improve understanding and find better ways to treat these tumors.

This study is creating a large database to collect information on people with rare diseases like amyloidosis, sarcoidosis, and Gaucher disease. Researchers will track patients' health over time, including their symptoms, treatments, and outcomes. The goal is to improve diagnosis …

This study is not testing a new treatment. Instead, it follows 300 people aged 14 and older with Cushing's syndrome to collect data on their health before and after standard treatments like surgery, medication, or radiation. The goal is to build a registry that helps doctors unde…

This study is testing a new, minimally invasive brain stimulation technique for people with cerebellar cognitive affective syndrome (CCAS), a condition that causes problems with thinking, mood, and movement. The researchers are enrolling 200 participants with Cushing's syndrome-r…