BREAST CANCER STAGE III

This early-stage study tests an experimental drug called BL-M17D1 in 120 adults with advanced solid tumors that have a specific protein (HER2) or a HER2 gene change. The main goals are to check the drug's safety, find the right dose, and see if it shrinks tumors. Participants mus…

This study looks at whether a 16-week exercise program can lower inflammation in fat tissue for women who have finished treatment for early-stage breast cancer. About 100 participants will take part. The goal is to see if movement can improve long-term health and reduce the risk …

This study tests a technique called axillary reverse mapping (ARM) to see if it can prevent lymphedema—painful arm swelling—after breast cancer surgery. About 534 women with early-stage breast cancer will be followed for 3 years. The goal is to preserve the arm's lymph drainage d…

This study looks at whether a targeted drug called palbociclib, taken as a pill for two years alongside standard hormone therapy, can replace chemotherapy for older adults (age 70+) with high-risk, hormone-receptor-positive, HER2-negative early breast cancer. The goal is to see i…

This study tests whether giving two drugs (taxotere and trastuzumab) before surgery can eliminate all signs of invasive cancer in Nigerian women with HER2-positive breast cancer. About 53 women with stage II or III breast cancer who have not had prior chemotherapy will receive th…

This study tests two vaccines designed to prevent breast cancer from returning in people who have already been treated for HER2-positive breast cancer. About 119 participants who had chemotherapy and surgery but still had cancer cells left will receive one of the vaccines. The go…

This study tests whether the DigniCap scalp cooling system can prevent chemotherapy-induced hair loss in Black patients with early-stage breast cancer. About 30 participants will use the cooling cap during at least four cycles of chemo. The goal is to see if hair loss is mild eno…

This study aims to create and test a shortened mindfulness program to help older African American women who have had breast cancer feel less depressed. About 23 women aged 65 and older with mild to moderate depression will take part. The goal is to see if the program is practical…

This study looks at how well a cardiopulmonary exercise test (CPET) can measure oxygen use in women with HER2-positive breast cancer who have mild heart problems from their cancer treatment. The goal is to see if this test can help predict how their heart and lungs will handle co…

This study tests a decision aid designed to help people with early-stage breast cancer (stages 0 to III) feel more confident and involved when choosing their surgery. The goal is to see if the tool works, especially for patients with lower income or education. Researchers will me…

This study looks at whether proton beam radiation causes less damage to the heart than standard photon radiation in people with left-sided breast cancer. About 60 participants will receive either proton or photon therapy, and their hearts will be checked with MRI scans. The goal …

This study looks at 100 people with stage II or III breast cancer who are already getting radiation. It compares proton beam radiation to standard X-ray radiation to see which one causes less damage to the heart and lungs. The goal is to learn which type of radiation is safer, no…