Could a pill replace chemo for older breast cancer patients?

NCT ID NCT03609047

Ongoing Disease control Sponsor: European Organisation for Research and Treatment of Cancer - EORTC Source: ClinicalTrials.gov ↗

First seen May 14, 2026 · Last updated May 14, 2026

Summary

This study looks at whether a targeted drug called palbociclib, taken as a pill for two years alongside standard hormone therapy, can replace chemotherapy for older adults (age 70+) with high-risk, hormone-receptor-positive, HER2-negative early breast cancer. The goal is to see if this approach can keep the cancer from coming back while avoiding the harsh side effects of chemo. About 366 participants are being followed to measure how long they stay cancer-free and their overall survival.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

AULSS 9 - Azienda Unita Locale Socio-Sanitaria N. 9-Mater Salutis Hospital

Legnago, Italy
AUSL Romagna - Rimini Hospital Unit - Infermi Hospital

Rimini, Italy
AZ Maria Middelares

Ghent, Belgium
AZ Nikolaas - Campus SL

Sint-Niklaas, Belgium
AZ Turnhout - Campus Sint Elisabeth

Turnhout, Belgium
Azienda Ospedaliera Citta della Salute e della Scienza di Torino - Azienda Ospedaliera Città della Salute e della Scienza di Torino - Ospedale Sant'Anna

Torino, Italy
Azienda Ospedaliero - Universitaria Policlinico di Modena

Modena, Italy
Azienda Ospedaliero Universitaria - Ospedali Riuniti

Torrette, Italy
Barts Health NHS Trust - St. Bartholomew'S Hospital

London, United Kingdom
Blackpool Teaching Hospitals NHS Foundation Trust - Blackpool Victoria Hospital-NHS Fundation Trust

Blackpool, United Kingdom
C.H.U. Sart-Tilman

Liège, Belgium
CHU de Limoges - Hopital Dupuytren

Limoges, France
CHU de Lyon - Hopital De La Croix Rousse

Lyon, France
CHU de Lyon - Hopital Lyon Sud

Pierre-Bénite, France
CHU-Lyon - Hopital Femme Mere Enfant

Brou, France
Casa di Cura La Maddalena S.P.A.

Palermo, Italy
Centre Francois Baclesse (CLCC)

Caen, France
Centre Henri Becquerel

Rouen, France
Centre Hospitalier Departemental Vendée

La Roche-sur-Yon, France
Centre Jean Perrin

Clermont-Ferrand, France
Centre Leon Berard

Lyon, France
Centre Oscar Lambret

Lille, France
Centro Hospitalar do Porto-- Hospital de Santo Antonio

Porto, Portugal
Centro Oncológico MD Anderson

Madrid, Spain
Champalimaud Clinical Center

Lisbon, Portugal
Cliniques Universitaires Saint-Luc

Brussels, Belgium
Faenza Hospital Unit - Ospedale degli Infermi

Faenza, Italy
Fundacion Instituto Valenciano De Oncologia

Valencia, Spain
Heilig Hartziekenhuis Lier

Lier, Belgium
Hospital Clinic Universitari de Barcelona

Barcelona, Spain
Hospital Clinico Universitario De Valencia

Valencia, Spain
Hospital Sant Joan de Reus

Reus, Spain
Hospital Severo Ochoa

Madrid, Spain
Hospital Universitari Arnau De Vilanova

Lleida, Spain
Hospital Universitari Vall d'Hebron

Barcelona, Spain
Hospital Universitario 12 De Octubre

Madrid, Spain
Hospital Universitario QuironSalud

Madrid, Spain
Hospital Universitario Virgen de Valme

Seville, Spain
Hospital prive du Confluent - Centre Catherine de Sienne

Nantes, France
Hospitales HM Sanchinarro-CIOCC

Madrid, Spain
IRCCS Azienda Ospedaliera Universitaria San Martino "IST" - IRCCS - AUO San Martino - IST

Genova, Italy
Institut Bergonie

Bordeaux, France
Institut Catala d'Oncologia - ICO Badalona - Hospital De Mataro

Barcelona, Spain
Institut Claudius Regaud

Toulouse, France
Institut Curie - l' Hopital de St Cloud

Saint-Cloud, France
Institut Jules Bordet-Hopital Universitaire ULB

Brussels, Belgium
Instituto Portugues De Oncologia - Instituto Portugues de Oncologia do Porto

Porto, Portugal
King Hussein Cancer Center

Amman, Jordan
Kliniken Essen-Mitte

Essen, Germany
Klinikum Frankfurt Hoechst GmbH

Frankfurt am Main, Germany
Kreiskrankenhaus Torgau

Torgau, Germany
Lugo Hospital Unit -Ospedale Umberto I

Lugo, Italy
Maria Sklodowska-Curie Memorial Cancer Centre - Maria Sklodowska - Curie's National Institute of Oncology - National Research Institute

Warsaw, Poland
Marienhospital Stuttgart

Stuttgart, Germany
Marienhospital Witten

Witten, Germany
Marienkrankenhaus Schwerte

Schwerte, Germany
Medical University Of Gdansk

Gdansk, Poland
NHS Borders - Borders General Hospital Melrose By-pass

Melrose, United Kingdom
NHS Lothian - Western General Hospital

Edinburgh, United Kingdom
ORTENAU KLINIKUM Offenburg-Gengenbach - Klinikum Offenburg Ebertplatz

Offenburg, Germany
Onkologie Haematologie Gemeinschaftspraxis - Studienzentrum Onkologie Ravensburg

Ravensburg, Germany
Ospedale B. Ramazzini

Carpi, Italy
Ospedale Civile Guastalla

Guastalla, Italy
Ospedale Degli Infermi

Biella, Italy
Ospedale Generale Regionale

Bolzano, Italy
Ospedale San Gerardo

Monza, Italy
Ospedale Santa Maria delle Croci

Ravenna, Italy
Riccione Hospital Unit - Ospedale Cervesi di Cattolica

Cattolica, Italy
Rimini Hospital Unit - Ospedale Sacra Famiglia

Novafeltria, Italy
Schwarzwald-Baar Klinikum

Villingen-Schwenningen, Germany
U.Z. Leuven - Campus Gasthuisberg

Leuven, Belgium
Universitaetskliniken Des Saarlandes

Homburg / Saar, Germany
Virgen del Rocio University Hospital

Seville, Spain

Conditions

Explore the condition pages connected to this study.

BREAST CANCER STAGE II BREAST CANCER STAGE III