BRCA2 MUTATION

This study is testing a new way to screen for breast cancer using a laser analysis of a blood sample (liquid biopsy). Researchers will compare results from 1,100 women—some with early-stage breast cancer and some without—to see if the laser test can accurately detect cancer. If s…

This study tests a surgery called radical fimbriectomy in 123 women with BRCA mutations who are at high risk for ovarian cancer but want to keep their ovaries. The surgery removes the fallopian tubes, where many of these cancers start, while leaving the ovaries intact to maintain…

This study looks at how to offer BRCA gene testing to more people, especially those of Ashkenazi Jewish descent, and make it a normal part of medical care. Over 5,400 participants will receive education and then decide if they want testing. Researchers will track who gets tested,…

This study looks at how well the immune system works in healthy people with BRCA1 or BRCA2 mutations. Researchers will give the seasonal flu vaccine to 50 participants and measure their antibody levels. The goal is to learn if these genetic changes affect overall immune health.

This study looks at whether a web-based educational program can help relatives of people with BRCA mutations understand genetic testing and decide if they want it. About 240 adults who are close relatives of someone with a BRCA mutation will be randomly assigned to use the online…

This study looks at 800 people with a type of breast cancer called lobular breast cancer or its early stage (LIN3). Researchers are checking blood samples for inherited gene changes using a panel of 113 genes. If a high-risk gene is found, preventive surgery may be offered; for m…