BIPOLAR AFFECTIVE DISORDER
Clinical trials for BIPOLAR AFFECTIVE DISORDER explained in plain language.
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New drug combo aims to tackle bipolar depression and suicidal thoughts
Disease control AVAILABLEThis study offers NRX-101, a combination of two drugs, to adults aged 18-65 with treatment-resistant bipolar depression and suicidal thoughts. Participants receive the medication from their own psychiatrist and undergo regular check-ins on mood, suicidal ideation, and side effect…
Matched conditions: BIPOLAR AFFECTIVE DISORDER
Sponsor: NeuroRx, Inc. • Aim: Disease control
Last updated Jul 22, 2026 00:00 UTC
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Could a sleep hormone tame bipolar mood swings?
Disease control Recruiting nowThis study tests whether adding melatonin (a natural sleep hormone) to standard treatment can help stabilize daily mood swings in people with bipolar disorder. Two hundred adults with bipolar disorder will take either a melatonin capsule or a placebo every day for six months. The…
Matched conditions: BIPOLAR AFFECTIVE DISORDER
Phase: PHASE2 • Sponsor: Lars Vedel Kessing • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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Could a seizure drug lift bipolar depression?
Symptom relief Recruiting nowThis phase 3 trial tests whether adding lacosamide to standard treatment helps people with bipolar disorder who are currently in a major depressive episode. Forty adults who haven't responded to at least two prior treatments will receive either lacosamide or a placebo for 12 week…
Matched conditions: BIPOLAR AFFECTIVE DISORDER
Phase: PHASE3 • Sponsor: University of Sao Paulo • Aim: Symptom relief
Last updated Jun 27, 2026 09:07 UTC
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App-Based therapy for depression put to the test in 325-Person study
Symptom relief Recruiting nowThis study is testing a mobile app that uses cognitive behavioral therapy (CBT) to help people with depression. Over 8 weeks, participants use the app for weekly AI-guided lessons and homework. The goal is to see if the app reduces depression symptoms and to explore how it affect…
Matched conditions: BIPOLAR AFFECTIVE DISORDER
Phase: NA • Sponsor: Peking University • Aim: Symptom relief
Last updated Jun 27, 2026 08:04 UTC
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Brain wave patterns and inflammation: a clue to ECT's effectiveness in older adults?
Knowledge-focused Recruiting nowThis study investigates whether brain wave patterns (measured by EEG) and inflammatory markers in the blood can help predict how well older adults with depression or bipolar disorder respond to electroconvulsive therapy (ECT). Researchers will compare EEG recordings and blood sam…
Matched conditions: BIPOLAR AFFECTIVE DISORDER
Sponsor: Istanbul University - Cerrahpasa • Aim: Knowledge-focused
Last updated Aug 02, 2026 00:00 UTC
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Mental health inpatients get a full medical check-up in new study
Knowledge-focused Recruiting nowThis study will carefully examine the physical and mental health of 100 adults admitted to NHS mental health wards. Researchers will review medical notes, do physical exams, and use questionnaires to measure conditions like bipolar disorder, schizophrenia, depression, and persona…
Matched conditions: BIPOLAR AFFECTIVE DISORDER
Sponsor: University of Edinburgh • Aim: Knowledge-focused
Last updated Jul 03, 2026 00:00 UTC
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New study aims to simplify fitness checks for those with severe mental illness
Knowledge-focused Recruiting nowThis study looks at how to measure cardiorespiratory fitness in people with severe mental illness, such as schizophrenia or bipolar disorder. Researchers will compare three different fitness tests in 50 patients and 25 healthy volunteers. The goal is to find a simple, accurate wa…
Matched conditions: BIPOLAR AFFECTIVE DISORDER
Sponsor: Bjorn H. Ebdrup • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC