ALZHEIMERS DISEASE

This study tests an experimental drug called trontinemab in 800 people with early Alzheimer's (mild memory loss to mild dementia). The goal is to see if it can slow down worsening of thinking and daily living skills over 72 weeks. Participants receive either the drug or a placebo…

This study tests a nasal spray called foralumab in 16 people with early Alzheimer's or mild cognitive impairment. The spray aims to reduce brain inflammation by calming overactive immune cells. Participants will use the spray three times a week for eight weeks and have brain scan…

This study tests if a surgery on neck lymph vessels can slow memory decline in people with moderate-to-severe Alzheimer's. 376 participants will either get the surgery plus usual care or just usual care. The goal is to see if the surgery helps clear brain waste and reduces dement…

This study tests an experimental drug called trontinemab in 800 people with early Alzheimer's (mild memory loss to mild dementia). The goal is to see if it can slow down the disease by measuring changes in thinking, memory, and daily activities over 72 weeks. Participants will re…

This study tests a drug called remternetug to see if it can prevent or slow Alzheimer's disease in people who have a genetic mutation that causes the disease. About 280 adults with no symptoms but high genetic risk will receive either the drug or a placebo. The goal is to stop ha…

This study tests whether experimental drugs can prevent or slow the buildup of harmful proteins in the brain that lead to Alzheimer's disease. It involves 280 adults who carry a genetic mutation that almost guarantees they will develop Alzheimer's. The goal is to see if early tre…

This study is a large pre-screening program to find people who may be eligible for future Alzheimer's drug trials. It involves a blood test for a key Alzheimer's protein and a memory test. No treatment is given in this study. Up to 13,000 adults with memory concerns will take par…

This study looks at how people with mild cognitive impairment (MCI) and Alzheimer's disease adjust their walking when conditions change, like walking on different surfaces. Researchers will measure walking patterns, memory, and thinking skills in 10 older adults. The goal is to b…

This study tests whether music therapy can alter key brain chemicals linked to Alzheimer's disease. Researchers will measure molecules like serotonin and amyloid-beta in the saliva of 60 older adults (healthy, mild impairment, and Alzheimer's). The goal is to provide scientific p…