ACNE VULGARIS

This study tests a cream called clascoterone (1%) against a placebo in 692 people aged 12 and older with moderate to severe acne. Participants apply the cream to their face twice daily for 12 weeks. The goal is to see if the cream safely clears acne better than a placebo.

This study tests three gels for mild-to-moderate acne: a standard clindamycin-retinoid cream, the same cream plus dexamethasone, and a new gel made from stem cell secretions (secretome). 189 people aged 15-40 will use one of the gels for 8 weeks. Researchers will count pimples, c…

This study tests whether a low daily dose of the acne medication isotretinoin can clear moderate to severe acne as effectively as the standard higher dose, but with fewer side effects like dry skin and chapped lips. About 164 adults aged 18-45 will be randomly assigned to one of …

This early-stage study tests a new drug called HB0043 in 21 adults with moderate to severe acne. The drug is a bispecific antibody that targets two inflammatory proteins (IL-17A and IL-36R) thought to drive acne. The goal is to see if it safely reduces acne lesions and improves s…

This study tests a new cream called KR230109 for mild to moderate acne. About 180 people aged 18 to 40 will use the cream or a placebo for 12 weeks. The goal is to see if the cream safely reduces pimples and skin bumps better than no treatment.

This study compares two prescription gels—metronidazole and clindamycin—to treat moderate acne in adults aged 18-35. Sixty participants will apply the assigned gel twice daily for 12 weeks. The goal is to see which gel reduces acne more effectively and causes fewer side effects l…

This study tests whether taking oral probiotics for 12 weeks can reduce acne lesions and lower inflammation in people with moderate acne. Researchers will compare probiotics to a placebo in 64 Pakistani patients aged 15-35. The goal is to find a safe, antibiotic-free option for a…

This study tests a new gel made with spironolactone against a standard acne gel (adapalene) in 40 people with mild to moderate acne. Each person will use the spironolactone gel on one side of their face and the standard gel on the other side. The goal is to see which gel works be…

This study tests a prescription gel called CABTREO in children aged 9 to 11 with moderate to severe acne. The gel combines three medicines to fight bacteria, unclog pores, and reduce inflammation. Researchers will check for side effects and measure how much acne improves over 12 …

This study compares a new topical gel containing dutasteride to a standard triple-combination gel (clindamycin, benzoyl peroxide, adapalene) for treating facial acne in adults. Fifty participants will use one gel on each side of their face for 12 weeks. The goal is to see which g…

This study looks at whether certain fat molecules (ceramides C16, C24, and S1P) in the blood are linked to acne severity. Researchers will compare 40 acne patients with 40 healthy volunteers aged 15-40. The goal is to better understand acne's causes, not to test a new treatment.