Ventricular septal defect

This trial tests whether a personalized exercise program before heart surgery can improve physical fitness in adults with congenital heart disease. Participants are randomly assigned to either usual care or a 6-week prehabilitation plan with aerobic, breathing, and strength exerc…

This study looks at how well a device can close a common heart hole called a ventricular septal defect (VSD) in children aged 6 months to 18 years. Instead of open-heart surgery, doctors use a small tube to place a device that plugs the hole. The goal is to see if this method is …

This study tests whether inserting a heart pump (IABP) early, before severe shock develops, can reduce deaths in patients who develop a hole in the heart after a heart attack. The trial will enroll 100 patients across 5 centers, randomly assigning half to receive the pump within …

This study enrolls children and young adults scheduled for heart surgery or catheterization under general anesthesia. Researchers place a forehead sensor that measures tissue oxygen levels and use an algorithm to estimate blood hemoglobin. The goal is to see if this noninvasive m…

This study looks at 115 children aged 6 months to 5 years who have a hole in the heart (VSD) and need surgery. Doctors want to see if an ultrasound probe placed in the food pipe (TEE) can measure heart pressure as accurately as the standard method using a thin tube (catheter) ins…

This study will check how accurate chest X-rays are at finding congenital heart disease in newborns. Researchers will study 60 babies in the NICU who show signs of heart problems. Each baby gets a chest X-ray within 24 hours and an echocardiogram within 72 hours. By comparing the…

This study looks at whether using clear, non-blood fluids to fill the heart-lung machine during surgery can reduce inflammation in infants having a hole in the heart repaired. Sixty babies aged 1 to 18 months will be enrolled. Researchers will measure inflammation markers and rec…

This study looks at whether children who had surgery to close a large hole in their heart (called a VSD) will catch up in growth. Researchers will measure weight, height, and BMI before and after the procedure in 58 children aged 1 month to 2 years. The goal is to see how long it…

This study will test a handheld device called IntraOx that uses light to measure oxygen levels in heart and liver tissue during complex heart surgery in children. The goal is to see if it can give surgeons useful information about blood flow without interfering with the operation…

This study looks at how the antibiotic cefazolin spreads in the chest tissue of 10 children after heart surgery for congenital heart disease. A small probe placed during surgery will measure drug levels over 36 hours. The goal is to create a computer model to help doctors give th…

This study will test a new, non-invasive ultrasound technique that captures brain blood flow in real time for infants with congenital heart disease. Researchers aim to understand how medical treatments and surgeries affect the brain, potentially explaining why some children later…