Urticaria

This trial tests a drug called briquilimab for adults with chronic spontaneous urticaria (CSU) — long-lasting hives and itching that don't get better with standard antihistamines or omalizumab. The study has three parts, with some participants getting the drug and others a placeb…

This phase 2 trial tested an oral drug called povorcitinib in 136 adults with chronic spontaneous urticaria (hives and itching lasting months) that standard antihistamines couldn't control. Participants took either povorcitinib or a placebo for 12 weeks to see if the drug reduced…

This study tested whether an artificial intelligence tool called Legit Health Plus can help doctors track the severity of chronic skin conditions like acne, psoriasis, and eczema from a distance. 160 participants used a smartphone app for 6 months to take photos of their skin and…

This completed study tested whether an AI device could help 16 doctors (10 general practitioners and 6 dermatologists) more accurately diagnose 13 different skin conditions, including melanoma, psoriasis, and acne. The doctors reviewed 29 medical images, first giving a diagnosis …

This study tested whether an artificial intelligence (AI) tool could help primary care doctors diagnose skin conditions more accurately. Nine doctors reviewed 30 images of various skin problems, first giving their own diagnosis and then a final diagnosis after seeing the AI's sug…

This study tested a daily tablet called NatureU Histra Disslove in 19 adults with chronic hives. Participants took one tablet before a main meal for 28 days. The study measured how well the tablet controlled hives, reduced symptoms, and improved quality of life. Results showed ch…

This study tests an experimental drug called EVO756 in 160 adults with moderate to severe chronic spontaneous urticaria (CSU), also known as chronic hives. Participants must have had hives for at least 3 months and not gotten enough relief from standard antihistamines. The goal i…

This study tested a single dose of a nasal spray called ARS-1 (intranasal epinephrine) in 21 adults who get frequent hives and itching. The goal was to see if the spray works faster and better than a placebo at reducing itch and hive scores during flare-ups. Participants were mon…

This study tested whether giving a steroid (cortancyl) along with an antihistamine (levocetirizine) is better than the antihistamine alone for treating sudden hives in the emergency department. 137 adults with acute urticaria (with or without mild angioedema) were enrolled. The m…

This study looks at people who have severe allergic reactions (anaphylaxis), especially when the cause is unknown. Researchers will do blood tests and bone marrow biopsies to find genetic or molecular clues. The goal is to understand what goes wrong in the body, not to test a new…

This study looks at why some people develop hives from physical triggers like cold, pressure, or sunlight. Researchers will test participants' skin reactions and collect blood and genetic samples to understand the role of immune cells and genes. The goal is to uncover the underly…