Trypanosomiasis

This study tested a single oral dose of acoziborole in 208 adults with sleeping sickness, a deadly parasitic disease. Participants took three tablets once and were monitored for 18 months. The goal was to see if this simple treatment could cure both early and late stages of the d…

This study tested whether sacubitril/valsartan (Entresto) works better than enalapril for people with heart failure caused by chronic Chagas disease. Over 900 adults with reduced heart function took part. The goal was to see if the drug could reduce heart-related deaths, hospital…

This early-phase trial tested the safety of an experimental drug called ICM20 in 13 adults with Chagas disease who had not been treated before. Participants took ICM20 along with the standard drug benznidazole. The main goal was to check for side effects and see how many people s…

This study tested whether a shorter, lower-dose course of the drug benznidazole works as well as the standard longer treatment for women with Chagas disease. Researchers enrolled 87 women in Argentina who had recently given birth and were infected with the parasite. The goal was …

This study tested a single dose of the oral drug acoziborole in 35 children aged 1 to 14 with sleeping sickness (g-HAT). The goal was to see how the drug works in the body and if it is safe and effective. This simpler treatment could help control the disease in remote areas where…

This pilot study tested a procedure called bilateral sympathectomy, which cuts certain nerves to the heart, in 45 Chagas disease patients with implantable defibrillators (ICDs) who had frequent dangerous heart rhythms. Participants were randomly assigned to receive the nerve-cutt…

This study tests whether offering a rapid diagnostic test for Chagas disease at a university in Argentina can help find undiagnosed infections and connect people to treatment. Participants are students, faculty, and staff aged 18 and older who get a quick finger-prick test during…

This early-stage study tested a new oral drug called AN2-502998 in 72 healthy adults aged 18 to 55. The main goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a placebo, and researchers monitored side effects and drug le…