Thrombophilia due to activated protein C resistance
MONDO:0008560A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance.
Also known as: thrombophilia 2 due to activated protein C resistance, thrombophilia due to activated protein C resistance, APC resistance, Activated Protein C resistance, Pccf deficiency, Proc cofactor deficiency, THPH2, resistance, APC
10 clinical trials for this condition and its sub-types.
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New shot aims to prevent dangerous clots in High-Risk patients
Disease control Recruiting nowThis early-stage study tests a single injection of CITY-FXI, a drug designed to lower clotting risk by targeting a protein called Factor XI. It includes healthy adults and those with Factor V Leiden or prothrombin G20210A mutations, which increase clot risk. The main goal is to c…
Phase: PHASE1 • Sponsor: City Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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New study prepares those with genetic clot risk for future trials
Knowledge-focused Recruiting nowThis study enrolls 100 adults who have or may have Factor V Leiden or Prothrombin G20210A mutations, which increase the risk of blood clots. Participants undergo genetic testing to confirm their status, then attend a site visit for basic health checks like blood pressure, ECG, an…
Sponsor: Richmond Research Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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New study tracks joint replacement success in bleeding disorder patients
Knowledge-focused Recruiting nowThis study looks at how well hip, knee, shoulder, and other joint replacement surgeries work in adults with inherited bleeding disorders like hemophilia. Researchers will collect information from medical records and follow patients over time to understand risks, complications, an…
Sponsor: Fondazione IRCCS Policlinico San Matteo di Pavia • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Scientists dig into genetic roots of rare bleeding disorders
Knowledge-focused Recruiting nowThis study looks at how blood cells interact and what goes wrong in inherited bleeding disorders like Glanzmann thrombasthenia. Researchers will analyze blood samples from up to 60 healthy volunteers and patients to find genetic defects. The goal is to better understand these con…
Sponsor: Rockefeller University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:55 UTC