Thrombophilia due to activated protein C resistance
MONDO:0008560A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance.
Also known as: thrombophilia 2 due to activated protein C resistance, thrombophilia due to activated protein C resistance, APC resistance, Activated Protein C resistance, Pccf deficiency, Proc cofactor deficiency, THPH2, resistance, APC
10 clinical trials for this condition and its sub-types.
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Battlefield plasma goes civil: can a powder save trauma victims?
Disease control CompletedThis study tested a freeze-dried plasma product that can be mixed with water in 6 minutes, avoiding the long thaw time of standard plasma. It included 42 trauma patients with severe bleeding who needed blood transfusions. The goal was to see if faster plasma delivery could improv…
Phase: PHASE3 • Sponsor: University Hospital, Lille • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Shorter blood thinner course after delivery may be safe for some women
Prevention CompletedThis study looked at 86 women with Factor V Leiden or Factor II mutations who had no history of blood clots. Researchers compared how long doctors prescribed blood thinners after childbirth (less than 2 weeks vs. 6 weeks) to see if shorter treatment was still effective at prevent…
Sponsor: Hospices Civils de Lyon • Aim: Prevention
Last updated Jun 27, 2026 12:04 UTC
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Mental health risks explored in women with pregnancy loss condition
Knowledge-focused CompletedThis study looked at how common major psychiatric disorders are in women with antiphospholipid syndrome (a blood clotting disorder) and similar pregnancy loss histories. Researchers compared three groups of women about 10 years after their initial diagnosis. The goal was to under…
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC