Thrombophilia due to activated protein C resistance

MONDO:0008560

A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance.

Also known as: thrombophilia 2 due to activated protein C resistance, thrombophilia due to activated protein C resistance, APC resistance, Activated Protein C resistance, Pccf deficiency, Proc cofactor deficiency, THPH2, resistance, APC

10 clinical trials for this condition and its sub-types.

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Broader categories

Disease (680) Hereditary disease (176) Hematologic disorder (170) Blood coagulation disease (53) Human disease (14) Coagulation protein disease (13) Thrombophilia (12) Inherited blood coagulation disorder (8) Disease of genetic or genomic mechanism (2) Disease by body system or component (0)

Trials to join now! 4 Not yet recruiting 1 Not yet finished but already full! 1 Completed 3 Terminated 1

AI takes on blood clotting: can ChatGPT guide surgeons on bleeding?

Knowledge-focused Terminated

This study evaluates whether artificial intelligence models can accurately interpret ROTEM blood clotting tests and recommend treatments for coagulopathy. Researchers will compare AI decisions to those of a panel of clinical experts using data from adults undergoing elective card…

Sponsor: Ondokuz Mayıs University • Aim: Knowledge-focused

Last updated Jul 04, 2026 00:00 UTC

Thrombophilia due to activated protein C resistance

Broader categories

AI takes on blood clotting: can ChatGPT guide surgeons on bleeding?